Sedative anxiolytic and analgesic effects of Urena sinuata L. leaf extract in animal models

Emran T. B., . and Rahman M. A., . Sedative anxiolytic and analgesic effects of Urena sinuata L. leaf extract in animal models. pp. 2069-2075. ISSN 22317546

The sedative and analgesic potential of Urena sinuata L. was investigated for the first time in this study. The crude methanol extract of Urena sinuata L. leaves was evaluated for its central nervous system (CNS) depressant effect using rodent behavioral models. Methanol extract of Urena sinuata at a dose of 400 mg/kg body weight displayed a suppressive effect on motor activity exploratory behavior (in hole cross and open field tests) and prolongation of thiopental induced sleeping time in mice. In the elevated plus-maze (EPM) test the same dose of methanol extract significantly (p 0.05) increased the time spent by the treated mice in EPM open arms. Analgesic potential of the extract was also evaluated for centrally acting analgesic activity using formalin induced licking response model and for peripheral analgesic action using acetic acid-induced writhing test and tail immersion tests. In formalin induced licking response model a significant (p 0.05) inhibition of pain compared to reference drug diclofenac sodium was observed. In acetic acid-induced writhing test and tail immersion test the extract at 200 mg/kg body weight produced a significant reduction of writhing response and pain respectively. These results evidenced the potential sedative and analgesic effects of Urena sinuata leaves.

Full text available from: Official URL: http://ifrj.upm.edu.my/21%20(05)%202014/49%20IFRJ%...

Abstract

The sedative and analgesic potential of Urena sinuata L. was investigated for the first time in this study. The crude methanol extract of Urena sinuata L. leaves was evaluated for its central nervous system (CNS) depressant effect using rodent behavioral models. Methanol extract of Urena sinuata at a dose of 400 mg/kg body weight displayed a suppressive effect on motor activity exploratory behavior (in hole cross and open field tests) and prolongation of thiopental induced sleeping time in mice. In the elevated plus-maze (EPM) test the same dose of methanol extract significantly (p 0.05) increased the time spent by the treated mice in EPM open arms. Analgesic potential of the extract was also evaluated for centrally acting analgesic activity using formalin induced licking response model and for peripheral analgesic action using acetic acid-induced writhing test and tail immersion tests. In formalin induced licking response model a significant (p 0.05) inhibition of pain compared to reference drug diclofenac sodium was observed. In acetic acid-induced writhing test and tail immersion test the extract at 200 mg/kg body weight produced a significant reduction of writhing response and pain respectively. These results evidenced the potential sedative and analgesic effects of Urena sinuata leaves.

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Item Type:	Article
AGROVOC Term:	Urena
AGROVOC Term:	Sedatives
AGROVOC Term:	Analgesics
AGROVOC Term:	Methanol
AGROVOC Term:	Cns (central nervous system)
AGROVOC Term:	Body weight
AGROVOC Term:	Thiopental
AGROVOC Term:	Mice
AGROVOC Term:	Formalin
AGROVOC Term:	Acetic acid
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 06:27
URI:	http://webagris.upm.edu.my/id/eprint/21892

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