Soursop (Anona muricata L.): Blood hematology and serum biochemistry of Sprague-Dawley rats

Mamot S., . and Mohamad Yusof Maskat, . and Hadijah H., . and Syahida M., . and Suri R., . Soursop (Anona muricata L.): Blood hematology and serum biochemistry of Sprague-Dawley rats. pp. 955-959. ISSN 2231-7546

This study was aimed to evaluate the effect of soursop (Annona muricata L.) extract on Sprague-Dawley rats subjected to in vivo 28-day repeated doses. The extract was given to the study group via force feeding. In the 28-day study Annona muricata L. extract was dosed at 0 (CD control dose) 0.5 (LD low dose) 1.0 (MD medium dose) 2.0g/kg (HD high dose) body weight. For control group distilled water was given to the animals. Administration of Annona muricata L. extract did not cause negative effect in blood hematology even though a statistically significant (p0.05) increase in platelet level was noted. Result from serum biochemical test showed that the consumption of the extract did not result in liver and kidney failure. The total antioxidant status (TAS) increased significantly as the dosages increased. However the incresase were within the normal laboratory limits.

Full text available from: Official URL: http://www.ifrj.upm.edu.my/19%20(03)%202012/(25)%2...

Abstract

This study was aimed to evaluate the effect of soursop (Annona muricata L.) extract on Sprague-Dawley rats subjected to in vivo 28-day repeated doses. The extract was given to the study group via force feeding. In the 28-day study Annona muricata L. extract was dosed at 0 (CD control dose) 0.5 (LD low dose) 1.0 (MD medium dose) 2.0g/kg (HD high dose) body weight. For control group distilled water was given to the animals. Administration of Annona muricata L. extract did not cause negative effect in blood hematology even though a statistically significant (p0.05) increase in platelet level was noted. Result from serum biochemical test showed that the consumption of the extract did not result in liver and kidney failure. The total antioxidant status (TAS) increased significantly as the dosages increased. However the incresase were within the normal laboratory limits.

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Item Type:	Article
AGROVOC Term:	Soursop
AGROVOC Term:	Extracts
AGROVOC Term:	Antioxidants
AGROVOC Term:	Hematology
AGROVOC Term:	Biochemistry
AGROVOC Term:	Polyphenols
AGROVOC Term:	Vitamins
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 06:27
URI:	http://webagris.upm.edu.my/id/eprint/22320

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