Citation
Faujan B H. Ahmad, . and Bruce J. Malcolm, . A simple and clean method for methoxymethylation of phenols. pp. 71-78. ISSN 0126-6128
Abstract
A simple and clean procedure for the preparation of methoxymethyl ethers (MOM CH2 OMe) of phenols having internally hydrogen bonded hydroxy groups is described. Thus treatment of 2 5-dihydroxybenzaldehyde (1) with a 1:1 mixture of methoxymethyl chloride-methyl acetate in ether at room temperature gives 2.5-bis-(methoxymethoxy)benzaldehyde (2) in 57 yield; under similar conditions the methoxymethyl ether (6) of salicylaldehyde was isolated in 75 yield. Yields of 61-81 not optimised of methoxymethyl ethers of several phenols lacking internal hydrogen bonding were also obtained.
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Abstract
A simple and clean procedure for the preparation of methoxymethyl ethers (MOM CH2 OMe) of phenols having internally hydrogen bonded hydroxy groups is described. Thus treatment of 2 5-dihydroxybenzaldehyde (1) with a 1:1 mixture of methoxymethyl chloride-methyl acetate in ether at room temperature gives 2.5-bis-(methoxymethoxy)benzaldehyde (2) in 57 yield; under similar conditions the methoxymethyl ether (6) of salicylaldehyde was isolated in 75 yield. Yields of 61-81 not optimised of methoxymethyl ethers of several phenols lacking internal hydrogen bonding were also obtained.
Additional Metadata
| Item Type: | Article |
|---|---|
| AGROVOC Term: | Phenols |
| AGROVOC Term: | Experiments |
| AGROVOC Term: | Solvent removal |
| AGROVOC Term: | Hydrogen |
| Geographical Term: | Malaysia |
| Depositing User: | Ms. Suzila Mohamad Kasim |
| Last Modified: | 28 Apr 2025 00:12 |
| URI: | http://webagris.upm.edu.my/id/eprint/22828 |
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