Susceptibility of HeLa (cancer-origin) cells to a sub-fraction of latex B-serum

Ong G. A., . and Yang K. L., . and Sunderasan E., . and Ong M. T., . and Lam K. L., . Susceptibility of HeLa (cancer-origin) cells to a sub-fraction of latex B-serum. pp. 117-124. ISSN 1511-1768

An increasing amount of cancer research is being directed towards the investigation of plantderived anticancer compounds many of which have been used in traditional herbal treatments for centuries. Extracts of Hevea brasiliensis the natural rubber tree had been demonstrated previously to have anticancer properties. In the present study latex fractions namely B- and C-sera were found to have anticancer properties in cell-based assay. Based on this result further screening was carried out using sub-fractions of latex B- and C-sera. This has led to the findings that one of the B-serum sub-fractions BHM is highly selective in reducing the growth of HeLa (cancer-origin) cells compared to that of Vero (non-cancer-origin) cells in MTT cell-based assay. The outcome has also paved the way for further investigations to elucidate the mechanisms of the BHM subfraction in reducing the growth of cancer-origin cells as well as to evaluate its potential role in cancer treatment.

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Abstract

An increasing amount of cancer research is being directed towards the investigation of plantderived anticancer compounds many of which have been used in traditional herbal treatments for centuries. Extracts of Hevea brasiliensis the natural rubber tree had been demonstrated previously to have anticancer properties. In the present study latex fractions namely B- and C-sera were found to have anticancer properties in cell-based assay. Based on this result further screening was carried out using sub-fractions of latex B- and C-sera. This has led to the findings that one of the B-serum sub-fractions BHM is highly selective in reducing the growth of HeLa (cancer-origin) cells compared to that of Vero (non-cancer-origin) cells in MTT cell-based assay. The outcome has also paved the way for further investigations to elucidate the mechanisms of the BHM subfraction in reducing the growth of cancer-origin cells as well as to evaluate its potential role in cancer treatment.

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Item Type:	Article
AGROVOC Term:	Cancer (disease)
AGROVOC Term:	Bark extracts
AGROVOC Term:	Cells
AGROVOC Term:	Bioassays
AGROVOC Term:	Latex plants
AGROVOC Term:	Cytotoxicity
AGROVOC Term:	Medicinal plants
AGROVOC Term:	Hevea brasiliensis
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 06:28
URI:	http://webagris.upm.edu.my/id/eprint/23049

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