Effect of different drying methods and solvent ratios on biological activities of Phyllanthus acidus extracts

Khoo L. W., . and Ahmed Mediani, . and Lee S. Y., . and Leong S. W., . and Siti Zaleha Abdul Ghani, . and Faridah Abas, . Effect of different drying methods and solvent ratios on biological activities of Phyllanthus acidus extracts. pp. 114-120. ISSN ISSN(Online):22317546

The main purpose of this study was to evaluate the antioxidant and -glucosidase inhibitory activities of Phyllanthus acidus. The P. acidus fruits were dried using three different methods namely oven (OD) air (AD) and freeze (FD) dryings and extracted with ethanol at different ratios (50 and 100). The proximate analysis and total phenolic content (TPC) as well as free radical scavenging and -glucosidase inhibitory activities were determined. The proximate analysis of P. acidus fruit indicated that all the dried samples contained potential nutrient contents. The highest TPC value -glucosidase inhibitory and antioxidant activities were observed for 50 ethanolic extract from OD method with TPC value of 28.39 mg GAE/g dried extract IC50 value of 12.394 g/mL and 64.17 inhibition respectively. The study revealed that phenolic compounds could be the main contributors to the antioxidant and -glucosidase inhibitory activities based on the Pearson correlation coefficients with R values of 95.0 and 73.8 respectively. The study could provide scientific evidence for some folk uses in the treatment of diseases related to the production of reactive oxygen species and oxidative stress.

Full text available from: Official URL: http://www.ifrj.upm.edu.my/24%20(01)%202017/(13).p...

Abstract

The main purpose of this study was to evaluate the antioxidant and -glucosidase inhibitory activities of Phyllanthus acidus. The P. acidus fruits were dried using three different methods namely oven (OD) air (AD) and freeze (FD) dryings and extracted with ethanol at different ratios (50 and 100). The proximate analysis and total phenolic content (TPC) as well as free radical scavenging and -glucosidase inhibitory activities were determined. The proximate analysis of P. acidus fruit indicated that all the dried samples contained potential nutrient contents. The highest TPC value -glucosidase inhibitory and antioxidant activities were observed for 50 ethanolic extract from OD method with TPC value of 28.39 mg GAE/g dried extract IC50 value of 12.394 g/mL and 64.17 inhibition respectively. The study revealed that phenolic compounds could be the main contributors to the antioxidant and -glucosidase inhibitory activities based on the Pearson correlation coefficients with R values of 95.0 and 73.8 respectively. The study could provide scientific evidence for some folk uses in the treatment of diseases related to the production of reactive oxygen species and oxidative stress.

[error in script]

Item Type:	Article
AGROVOC Term:	Phyllanthus acidus
AGROVOC Term:	Drying
AGROVOC Term:	Extraction
AGROVOC Term:	Proximate analysis
AGROVOC Term:	Free radicals
AGROVOC Term:	Chemical reagents
AGROVOC Term:	Dried fruits
AGROVOC Term:	Ethanol
AGROVOC Term:	Phenolic content
AGROVOC Term:	reactive oxygen species
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 06:28
URI:	http://webagris.upm.edu.my/id/eprint/23255

Actions (login required)

View Item