Production of natural rubber latex gloves with low extractable protein content: some practical recommendations

Ng K. P., . and Yip Esah, . and Mok K. L., . Production of natural rubber latex gloves with low extractable protein content: some practical recommendations. pp. 87-95. ISSN 0127-7065

With the reported incidence of Type 1 hypersensitivity associated with the presence of residual water-soluble proteins in latex products there is an urgent need to produce latex gloves with minimum extractable proteins. The current practice of wet gel leaching for a short period of time is inadequate in reducing the extractable proteins. This study shows that an additional leaching operation after drying is necessary. The most effective means is the use of a re-centrifuged prevulcanised latex with a combination of wet gel leaching and dry-film leaching or direct water spraying. Under the most favourable conditions an extractable protein content of approximately 0.03 mg/g can be achieved. Physical properties of the low extractable protein gloves are found to meet the requirements of ASTM D-3578-91 for natural rubber examination gloves. Their allergic response as tested clinically on latex-sensitive patients by a skin-prick test is found to be highly negative.

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Abstract

With the reported incidence of Type 1 hypersensitivity associated with the presence of residual water-soluble proteins in latex products there is an urgent need to produce latex gloves with minimum extractable proteins. The current practice of wet gel leaching for a short period of time is inadequate in reducing the extractable proteins. This study shows that an additional leaching operation after drying is necessary. The most effective means is the use of a re-centrifuged prevulcanised latex with a combination of wet gel leaching and dry-film leaching or direct water spraying. Under the most favourable conditions an extractable protein content of approximately 0.03 mg/g can be achieved. Physical properties of the low extractable protein gloves are found to meet the requirements of ASTM D-3578-91 for natural rubber examination gloves. Their allergic response as tested clinically on latex-sensitive patients by a skin-prick test is found to be highly negative.

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Item Type:	Article
AGROVOC Term:	Natural rubber
AGROVOC Term:	Latex
AGROVOC Term:	Protein content
AGROVOC Term:	Hypersensitivity
AGROVOC Term:	Proteins
AGROVOC Term:	Leaching
AGROVOC Term:	Centrifugation
AGROVOC Term:	Spraying
AGROVOC Term:	Skin tests
AGROVOC Term:	Physical properties
Geographical Term:	Malaysia
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	28 Apr 2025 04:30
URI:	http://webagris.upm.edu.my/id/eprint/23408

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