In vivo evaluation of snake fruit Kombucha as hyperglycemia therapeutic agent


Citation

Kalsum U., . and Apriyadi T. E., . and Estiasih T., . and Srianta I., . and Zubaidah E., . and Blanc P. J., . and Widyastuti E., . In vivo evaluation of snake fruit Kombucha as hyperglycemia therapeutic agent. pp. 453-457. ISSN 2231-7546

Abstract

This research was a part of development of functional beverage through fermentation of snake fruit juice with Kombucha consortium. The aim of this research was to study on in vivo evaluation of snake fruit Kombucha as hyperglycemia therapeutic agent. The snake fruit (Salak Suwaru cultivar) juice was fermented for 14 days with the Kombucha consortium. Streptozotocin induced diabetic rats were used in the in vivo evaluation. The snake fruit Kombucha was orally administerred at different level for 28 days. The results revealed the treatment showed a significant fasting plasma glucose reduction in a range of 31-59 consistent with improving of blood serum superoxide dismutase activity and malondialdehyde level. Immunohistochemical staining of pancreatic tissue proved a regeneration of the pancreatic beta cells in the groups of snake fruit Kombucha treatment compared to control group. Snake fruit Kombucha was proven as a hyperglycemia therapeutic agent in diabetic rats model.


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Abstract

This research was a part of development of functional beverage through fermentation of snake fruit juice with Kombucha consortium. The aim of this research was to study on in vivo evaluation of snake fruit Kombucha as hyperglycemia therapeutic agent. The snake fruit (Salak Suwaru cultivar) juice was fermented for 14 days with the Kombucha consortium. Streptozotocin induced diabetic rats were used in the in vivo evaluation. The snake fruit Kombucha was orally administerred at different level for 28 days. The results revealed the treatment showed a significant fasting plasma glucose reduction in a range of 31-59 consistent with improving of blood serum superoxide dismutase activity and malondialdehyde level. Immunohistochemical staining of pancreatic tissue proved a regeneration of the pancreatic beta cells in the groups of snake fruit Kombucha treatment compared to control group. Snake fruit Kombucha was proven as a hyperglycemia therapeutic agent in diabetic rats model.

Additional Metadata

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Item Type: Article
AGROVOC Term: Arecaceae
AGROVOC Term: Salacca
AGROVOC Term: Fruit juices
AGROVOC Term: Fermentation
AGROVOC Term: In vivo experimentation
AGROVOC Term: Clinical experimentation
AGROVOC Term: Hyperglycaemia
AGROVOC Term: Blood glucose
AGROVOC Term: Diabetes
AGROVOC Term: Disease control methods
Depositing User: Ms. Suzila Mohamad Kasim
Last Modified: 24 Apr 2025 06:28
URI: http://webagris.upm.edu.my/id/eprint/24038

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