Safety assessment of tocotrienol supplementation in subjects with metabol syndrome: a randomised control trial

Kanga Rani Selvaduray, . and Puvaneswari Meganathan, . and Fu Ju Yen, . and Kalanithi Nesaretnam, . and Yuen Kah Hay, . and Lai Oi Ming, . and Gan Yee Lin, . and Chew Boon How, . and Teng Kim-Tiu, . Safety assessment of tocotrienol supplementation in subjects with metabol syndrome: a randomised control trial. pp. 34-43. ISSN 1511-2780

Previous studies have reported that tocotrienols (T3) possess many distinct properties such as antioxidant cardioprotective neuroprotective anti-cancer anti-inflammatory and anti-angiogenic which are beneficial for the improvement of human health. However there is limited data available on the safety assessment of T3 compared to tocopherols (T). A randomised double-blinded cross-over and placebo-controlled human clinical trial was conducted to determine the safety and tolerance of T3 supplementation in 31 subjects with metabolic syndrome. The subjects were supplemented with tocotrienol-rich fraction (TRF) 200 mg or placebo capsules twice daily for two weeks followed by a post-intervention visit. Results showed that T3 supplementation had no significant adverse effect on the red blood cell (RBC) white blood cell (WBC) and platelet counts between TRF (5.10 0.78 x 1012 litre-1 7.35 1.59 x 109 litre-1 279.45 73.86 x 109 litre-1 respectively) and placebo interventions (5.13 0.76 x 1012 litre-1 7.25 1.95 x 109 litre-1 267.45 68.72 x 109 litre-1 respectively). Measures of serum aspartate aminotransferase (AST) serum alanine aminotransferase (ALT)) and albumin did not differ between TRF (25.68 10.72 IU litre-1 38.26 24.74 IU litre-1 43.61 2.26 g litre-1 respectively) and placebo interventions (27.39 16.44 IU litre-1 42.23 33.58 IU litre-1 43.68 2.15 g litre-1 respectively).This study indicated that supplementation with T3 at the dosage of 400 mg per day for 14 days did not induce haematoxicity and hepatotoxicity in subjects with metabolic syndrome.

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Abstract

Previous studies have reported that tocotrienols (T3) possess many distinct properties such as antioxidant cardioprotective neuroprotective anti-cancer anti-inflammatory and anti-angiogenic which are beneficial for the improvement of human health. However there is limited data available on the safety assessment of T3 compared to tocopherols (T). A randomised double-blinded cross-over and placebo-controlled human clinical trial was conducted to determine the safety and tolerance of T3 supplementation in 31 subjects with metabolic syndrome. The subjects were supplemented with tocotrienol-rich fraction (TRF) 200 mg or placebo capsules twice daily for two weeks followed by a post-intervention visit. Results showed that T3 supplementation had no significant adverse effect on the red blood cell (RBC) white blood cell (WBC) and platelet counts between TRF (5.10 0.78 x 1012 litre-1 7.35 1.59 x 109 litre-1 279.45 73.86 x 109 litre-1 respectively) and placebo interventions (5.13 0.76 x 1012 litre-1 7.25 1.95 x 109 litre-1 267.45 68.72 x 109 litre-1 respectively). Measures of serum aspartate aminotransferase (AST) serum alanine aminotransferase (ALT)) and albumin did not differ between TRF (25.68 10.72 IU litre-1 38.26 24.74 IU litre-1 43.61 2.26 g litre-1 respectively) and placebo interventions (27.39 16.44 IU litre-1 42.23 33.58 IU litre-1 43.68 2.15 g litre-1 respectively).This study indicated that supplementation with T3 at the dosage of 400 mg per day for 14 days did not induce haematoxicity and hepatotoxicity in subjects with metabolic syndrome.

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Item Type:	Article
AGROVOC Term:	Tocotrienols
AGROVOC Term:	Vitamin e
AGROVOC Term:	Supplements
AGROVOC Term:	Human diseases
AGROVOC Term:	Metabolic disorders
AGROVOC Term:	Absorption
AGROVOC Term:	Blood sampling
AGROVOC Term:	Centrifugation
AGROVOC Term:	Body weight
AGROVOC Term:	Statistical analysis
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 06:28
URI:	http://webagris.upm.edu.my/id/eprint/24183

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