Coated gellan gum hydrogel as a drug carrier for colon targeted drug delivery


Citation

Hamdan Suhaimi, . and Laili Che Rose, . and Chan Siok Yee, . and Nurfaezatil Farhana Norazemi, . and Khairul Anuar Mat Amin, . Coated gellan gum hydrogel as a drug carrier for colon targeted drug delivery. pp. 36-41. ISSN 1823-8556

Abstract

Oral drug delivery system provides a simple mechanism and more convenient approach towards colon cancer treatment. Yet oral drug administration also faced some limitation passing through in the gastrointestinal tract before reaching the targeted area. In this work a coated gellan gum hydrogel was proposed to increase the treatment efficiency in colon cancer treatment through oral administration using dip coating process. Two types of coating materials hydrocarbon (eicosane and docosane) and fatty acid (C12 and C16) were used. Single and mixed coating materials were tested using DSC and the results obtained showed that the best coating material was hydrocarbon with a weight ratio of 40:60 of eicosane and docosane (E:D).


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Abstract

Oral drug delivery system provides a simple mechanism and more convenient approach towards colon cancer treatment. Yet oral drug administration also faced some limitation passing through in the gastrointestinal tract before reaching the targeted area. In this work a coated gellan gum hydrogel was proposed to increase the treatment efficiency in colon cancer treatment through oral administration using dip coating process. Two types of coating materials hydrocarbon (eicosane and docosane) and fatty acid (C12 and C16) were used. Single and mixed coating materials were tested using DSC and the results obtained showed that the best coating material was hydrocarbon with a weight ratio of 40:60 of eicosane and docosane (E:D).

Additional Metadata

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Item Type: Article
AGROVOC Term: Coating materials
AGROVOC Term: Gums
AGROVOC Term: Colon
AGROVOC Term: Cancer (disease)
AGROVOC Term: Digestive system
AGROVOC Term: Oral administration
AGROVOC Term: Glycerin
AGROVOC Term: Fatty acids
AGROVOC Term: Absorbance
AGROVOC Term: Heating
Depositing User: Ms. Suzila Mohamad Kasim
Last Modified: 24 Apr 2025 06:28
URI: http://webagris.upm.edu.my/id/eprint/24214

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