Development of carrageenan hydrogel as a sustained release matrix containing tocotrienol-rich palm-based vitamin E

Cheong Mei Yee, . and Zafarizal Aldrin Azizul Hasan, . and Norashikin Ahmad, . and Hazimah Abu Hassan, . Development of carrageenan hydrogel as a sustained release matrix containing tocotrienol-rich palm-based vitamin E. pp. 373-386. ISSN 1511-2780

Topically applied hydrogel system as a general therapeutic mask for transdermal delivery of hydrophobic actives is not efficient due to the differences in polarity between the actives and the polymer network. This work presents a study on developing hydrogels based on carrageenan as a matrix for the delivery of a hydrophobic type of active i.e. tocotrienol-rich palm-based vitamin E (TRPE) into the skin. The strength and flexibility of the hydrogel were increased by the inclusion of guar gum potassium citrate and glycerine. The thermogravimetric analysis (TGA) results indicated a higher quantity of water in the hydrogel with glycerine while differential scanning calorimetry (DSC) showed three types of water molecules existed in the hydrogel. The hydrogel was non-irritating according to OECD Test Guideline No. 439 for in vitro skin irritation test. The hydrogel with TRPE fluids was able to permeate the polysulfone membrane and bioavailability of TRPE improved with the inclusion of PEG-40 hydrogenated castor oil mixture. Therefore a carrageenan-based hydrogel with locust bean guar gum glycerine potassium citrate and TRPE was successfully developed with good strength and flexibility and without any potential irritancy. The good bioavailability of TRPE-loaded in the hydrogel can be used for skin care application.

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Abstract

Topically applied hydrogel system as a general therapeutic mask for transdermal delivery of hydrophobic actives is not efficient due to the differences in polarity between the actives and the polymer network. This work presents a study on developing hydrogels based on carrageenan as a matrix for the delivery of a hydrophobic type of active i.e. tocotrienol-rich palm-based vitamin E (TRPE) into the skin. The strength and flexibility of the hydrogel were increased by the inclusion of guar gum potassium citrate and glycerine. The thermogravimetric analysis (TGA) results indicated a higher quantity of water in the hydrogel with glycerine while differential scanning calorimetry (DSC) showed three types of water molecules existed in the hydrogel. The hydrogel was non-irritating according to OECD Test Guideline No. 439 for in vitro skin irritation test. The hydrogel with TRPE fluids was able to permeate the polysulfone membrane and bioavailability of TRPE improved with the inclusion of PEG-40 hydrogenated castor oil mixture. Therefore a carrageenan-based hydrogel with locust bean guar gum glycerine potassium citrate and TRPE was successfully developed with good strength and flexibility and without any potential irritancy. The good bioavailability of TRPE-loaded in the hydrogel can be used for skin care application.

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Item Type:	Article
AGROVOC Term:	Carrageenans
AGROVOC Term:	Bioavailability
AGROVOC Term:	Ceratonia siliqua
AGROVOC Term:	Cyamopsis tetragonoloba
AGROVOC Term:	Absorption
AGROVOC Term:	Carobs
AGROVOC Term:	Castor beans
AGROVOC Term:	Castor oil
AGROVOC Term:	Cluster beans
AGROVOC Term:	Glycerin
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 06:28
URI:	http://webagris.upm.edu.my/id/eprint/24280

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