Safety assessment of Bacillus thuringiensis-based products using eye/ocular irritation on rabbits

Mohamed Mazmira Mohd Masri, . and Siti Ramlah Ahmad Ali, . and Norman Kamarudin, . and Ahmad Kushairi, . and Mohd Najib Ahmad, . and Mohd Zaini Asmawi, . Safety assessment of Bacillus thuringiensis-based products using eye/ocular irritation on rabbits. pp. 10-15. ISSN 1511-2780

To register with the National Pesticide Board Malaysia a pesticide must undergo laboratory testing for short-term and long-term health effects. Laboratory animals such as rabbits are tested with high doses of Bacillus thuringiensis (Bt) products to assess the potential to produce lesions or reversal effects on eyes. The objective of this study was to investigate the effect of Bafog-1 (S) and Ecobac-1 (EC) against young New Zealand albino rabbits eye or the potential of Bt products to cause eye or ocular irritation. The test was conducted according to the Guidelines of International Organisation for Standardisation 10993-10 Test for Irritation and Sensitisation. The results showed that Bafog-1 (S) is not an irritant to rabbits whereas Ecobac-1 (EC) produced irritation that was reversal after 120 hr of instillation. The Bt as an environmental-friendly microbial insecticide was generally non-toxic to human domestic animals and vertebrates. Therefore Bt is recommended to be used as a safe microbial insecticide for controlling bagworm in oil palm plantation.

Full text available from: Official URL: http://jopr.mpob.gov.my/safety-assessment-of-bacil...

Abstract

To register with the National Pesticide Board Malaysia a pesticide must undergo laboratory testing for short-term and long-term health effects. Laboratory animals such as rabbits are tested with high doses of Bacillus thuringiensis (Bt) products to assess the potential to produce lesions or reversal effects on eyes. The objective of this study was to investigate the effect of Bafog-1 (S) and Ecobac-1 (EC) against young New Zealand albino rabbits eye or the potential of Bt products to cause eye or ocular irritation. The test was conducted according to the Guidelines of International Organisation for Standardisation 10993-10 Test for Irritation and Sensitisation. The results showed that Bafog-1 (S) is not an irritant to rabbits whereas Ecobac-1 (EC) produced irritation that was reversal after 120 hr of instillation. The Bt as an environmental-friendly microbial insecticide was generally non-toxic to human domestic animals and vertebrates. Therefore Bt is recommended to be used as a safe microbial insecticide for controlling bagworm in oil palm plantation.

[error in script]

Item Type:	Article
AGROVOC Term:	Bacillus thuringiensis
AGROVOC Term:	Biological control agents
AGROVOC Term:	Rabbits
AGROVOC Term:	Eyes
AGROVOC Term:	Fermentation
AGROVOC Term:	Sedimentation
AGROVOC Term:	Instillation
AGROVOC Term:	Temperature
AGROVOC Term:	Bioreactors
AGROVOC Term:	Swelling
Geographical Term:	Malaysia
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	28 Apr 2025 07:23
URI:	http://webagris.upm.edu.my/id/eprint/24318

Actions (login required)

View Item