Phytochemicals and cytotoxic studies of Zingiber cassumunar Roxb.

Mohd Zulkhairi Azid, . and Mohd Aspollah Sukari, . and Ee Gwendoline Cheng Lian, . and Ahmad Bustamam Abdul, . Phytochemicals and cytotoxic studies of Zingiber cassumunar Roxb. pp. 187-197. ISSN 1394-9829

Zingiber cassumunar belongs to the family Zingiberaceae and is locally known as bonglai in Malay and plai among Thais. It has been traditionally used as treatment for women after giving birth or during confinement. Extraction and isolation of phytochemical compounds from the rhizome of Zingiber cassumunar Roxb. using various chromatographic techniques identified five compounds namely cis-3-(3 4-dimethoxyphenyl)-4-(E)-3 4-dimethoxystyrylcyclo-hex1-ene (1) (E)-4-(3 4-dimethoxyphenyl) but-3-en-1-ol (2) 3 4-dimethoxybenzoic acid (3) 8-(13 14-dimethoxyphenyl)-2-methoxynaphto-1 4-quinone (4) and -sitosterol (5). Structure elucidation of these compounds was carried out by various spectroscopic means. The cytotoxic activity of isolated compounds against human T-acute lymphoblastic leukemia cancer cells (CEMss) and human cervical cancer cells (HeLa) were carried out using MTT assay. Only mthe chloroform extract showed strong activity against CEMss cancer cells with IC50 values of 9.20 0.02 g/ml. Compounds (1) (2) and (4) showed strong cytotoxicity activity against HeLa cancer cells with IC50 values 15 g/ ml whilst compounds (1) and (4) demonstrated moderate cytotoxicity activity against CEMss cells with 1C50 values of 28.34 0.39 g/ml and 25.96 0.94 g/ml respectively. Therefore Zingiber cassumunar has high potential to be commercially domesticated based on the anti-cancer properties of its compounds.

Full text available from: Official URL: http://jtafs.mardi.gov.my/jtafs/45-2/cytotoxic.pdf

Abstract

Zingiber cassumunar belongs to the family Zingiberaceae and is locally known as bonglai in Malay and plai among Thais. It has been traditionally used as treatment for women after giving birth or during confinement. Extraction and isolation of phytochemical compounds from the rhizome of Zingiber cassumunar Roxb. using various chromatographic techniques identified five compounds namely cis-3-(3 4-dimethoxyphenyl)-4-(E)-3 4-dimethoxystyrylcyclo-hex1-ene (1) (E)-4-(3 4-dimethoxyphenyl) but-3-en-1-ol (2) 3 4-dimethoxybenzoic acid (3) 8-(13 14-dimethoxyphenyl)-2-methoxynaphto-1 4-quinone (4) and -sitosterol (5). Structure elucidation of these compounds was carried out by various spectroscopic means. The cytotoxic activity of isolated compounds against human T-acute lymphoblastic leukemia cancer cells (CEMss) and human cervical cancer cells (HeLa) were carried out using MTT assay. Only mthe chloroform extract showed strong activity against CEMss cancer cells with IC50 values of 9.20 0.02 g/ml. Compounds (1) (2) and (4) showed strong cytotoxicity activity against HeLa cancer cells with IC50 values 15 g/ ml whilst compounds (1) and (4) demonstrated moderate cytotoxicity activity against CEMss cells with 1C50 values of 28.34 0.39 g/ml and 25.96 0.94 g/ml respectively. Therefore Zingiber cassumunar has high potential to be commercially domesticated based on the anti-cancer properties of its compounds.

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Item Type:	Article
AGROVOC Term:	Zingiber
AGROVOC Term:	Cytotoxicity
AGROVOC Term:	Zingiberaceae
AGROVOC Term:	Rhizomes
AGROVOC Term:	Chromatography
AGROVOC Term:	Sitosterol
AGROVOC Term:	Cancer (disease)
AGROVOC Term:	Chloroform
AGROVOC Term:	Ginger
AGROVOC Term:	Extraction
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 06:28
URI:	http://webagris.upm.edu.my/id/eprint/24386

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