Citation
Kharis Zahid, . and Azimahtol Hawariah Lope Pihie, . and Normah Ahamad, . and Aishah Ramli, . Morinda citrifolia extract inhibits proliferation of non-small humanlung cancer cell line NCI-H23 via apoptosis by modulating the Bax:Bcl-2 ratio. pp. 203-209. ISSN 1394-9829
Abstract
The involvement of Bcl-2 gene family in cells apoptosis mechanism is well described in many studies against cell death after treatment with anticancer drugs. Previously the potential of M. citrifolia extract to inhibit proliferation and induce apoptosis in human lung adenocarcinoma cell growth was carried out. The mechanism involved in apoptosis of NCI-H23 cells after treated with M.citrifolia extract was studied. A search for the molecular mechanism revealed that M.citrifolia extract burden decrease the expression of the pro-apoptotic protein Bcl-2 but the level of Bax protein remain. These in consequence elevated the ratio of Bax:Bcl-2 in apoptotic cell. These findings indicated that the apoptotic events by M. citrifolia extract were associated with down-regulation of Bcl-2 protein expression in NCI-H23 cells.
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Abstract
The involvement of Bcl-2 gene family in cells apoptosis mechanism is well described in many studies against cell death after treatment with anticancer drugs. Previously the potential of M. citrifolia extract to inhibit proliferation and induce apoptosis in human lung adenocarcinoma cell growth was carried out. The mechanism involved in apoptosis of NCI-H23 cells after treated with M.citrifolia extract was studied. A search for the molecular mechanism revealed that M.citrifolia extract burden decrease the expression of the pro-apoptotic protein Bcl-2 but the level of Bax protein remain. These in consequence elevated the ratio of Bax:Bcl-2 in apoptotic cell. These findings indicated that the apoptotic events by M. citrifolia extract were associated with down-regulation of Bcl-2 protein expression in NCI-H23 cells.
Additional Metadata
| Item Type: | Article |
|---|---|
| AGROVOC Term: | Morinda citrifolia |
| AGROVOC Term: | Tissue proliferation |
| AGROVOC Term: |   Lungs |
| AGROVOC Term: | Cancer (disease) |
| AGROVOC Term: | Apoptosis |
| AGROVOC Term: | Adenocarcinoma |
| AGROVOC Term: | Evaporators |
| AGROVOC Term: | Chloroform |
| AGROVOC Term: | Antibiotics |
| AGROVOC Term: | Viability |
| Depositing User: | Ms. Suzila Mohamad Kasim |
| Last Modified: | 24 Apr 2025 06:29 |
| URI: | http://webagris.upm.edu.my/id/eprint/24552 |
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