Elevation of p53 level in human lung cancer cell line NCI-H23 apoptosis treated by Morinda citrifolia extract

Kharis Zahid, . and Azimahol Hawariah Lope Pihie, . and Normah Ahamad, . Elevation of p53 level in human lung cancer cell line NCI-H23 apoptosis treated by Morinda citrifolia extract. pp. 77-84. ISSN 1394-9829

Effective p53 is a suppressor protein that acts as a key of transcription factor to multi cellular interaction. Its function is to balance between the cell growth and dead cells in the living system and plays an important role in deletion of cell growing and apoptosis induction. Studies have shown that p53 is activated when the signals are received by the cells due to stimulation from the inner or outer stressors. The accumulation of p53 resulted in either cell cycle arrest or apoptosis induction to the cells. An involvement of p53 in apoptosis has been reported in cells death treated by anticancer drug. Result showed that M. citrifolia extract inhibited and induced apoptosis in human lung adenocarcinoma. In mechanism study apoptosis of NCI-H23 treated with M. citrifolia extract increased the expression of p53 level in the cells. Elevation of p53 induces apoptosis through either extrinsic or intrinsic pathway by dispolarisation and increase sensitivity cells towards induction of apoptosis. The findings suggest that apoptotic event induced by M. citrifolia was through modulation of elevated p53 in the NCIH23 cells and thus promoting activation of down stream cascades involved in apoptosis mechanism.

Full text available from: Official URL: http://jtafs.mardi.gov.my/jtafs/37-1/Human%20Lung%...

Abstract

Effective p53 is a suppressor protein that acts as a key of transcription factor to multi cellular interaction. Its function is to balance between the cell growth and dead cells in the living system and plays an important role in deletion of cell growing and apoptosis induction. Studies have shown that p53 is activated when the signals are received by the cells due to stimulation from the inner or outer stressors. The accumulation of p53 resulted in either cell cycle arrest or apoptosis induction to the cells. An involvement of p53 in apoptosis has been reported in cells death treated by anticancer drug. Result showed that M. citrifolia extract inhibited and induced apoptosis in human lung adenocarcinoma. In mechanism study apoptosis of NCI-H23 treated with M. citrifolia extract increased the expression of p53 level in the cells. Elevation of p53 induces apoptosis through either extrinsic or intrinsic pathway by dispolarisation and increase sensitivity cells towards induction of apoptosis. The findings suggest that apoptotic event induced by M. citrifolia was through modulation of elevated p53 in the NCIH23 cells and thus promoting activation of down stream cascades involved in apoptosis mechanism.

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Item Type:	Article
AGROVOC Term:	Morinda citrifolia
AGROVOC Term:	Cancer (disease)
AGROVOC Term:	Apoptosis
AGROVOC Term:	Cell cycle
AGROVOC Term:	Adenocarcinoma
AGROVOC Term:	Cascades
AGROVOC Term:	Maturity
AGROVOC Term:	Chloroform
AGROVOC Term:	Protein hydrolysate
AGROVOC Term:	Polarization
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 06:29
URI:	http://webagris.upm.edu.my/id/eprint/24562

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