Irreversible nanotoxicity of silicon dioxide nanoparticles in the freshwater fish Oreochromis mossambicus (Peters 1852)

Vidya P.V., . and Chitra K.C., . Irreversible nanotoxicity of silicon dioxide nanoparticles in the freshwater fish Oreochromis mossambicus (Peters 1852). pp. 146-160. ISSN 0116-6514

Silicon dioxide nanoparticles (SiO‚‚-NPs) is widely used in the fields of medicine engineering and industries. In the present study sublethal concentration (12 mg.L -) of SiO‚‚ -NPs was exposed to the freshwater fish Oreochromis mossambicus (Peters 1852) for short-term (24 72 and 96 h) and long-term (15 30 and 60 days) durations maintaining a control group. Gill tissues showed significant (P 0.05) reduction in the activities of antioxidant enzymes superoxide dismutase catalase glutathione reductase and glutathione peroxidase with a concomitant increase in the production of hydrogen peroxide and lipid peroxidation. Liver tissue also showed induction of oxidative stress which was evident by the significant decrease in the activities of antioxidant enzymes and generation of hydrogen peroxide and lipid peroxidation. In brain tissue the alteration of antioxidant defence system was more prominent only after 96 h. The activities of tissue marker enzymes were also decreased in gill liver and brain tissues indicating tissue-specific nanotoxicity. The reversible of treatment for 60 days showed no withdrawal effect of nanoparticles in all tissues. The present results conclude that exposure to silicon dioxide nanoparticles induced oxidative stress and the effects are found irreversible in the gill liver and brain tissues of the fish O. mossambicus.

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Abstract

Silicon dioxide nanoparticles (SiO‚‚-NPs) is widely used in the fields of medicine engineering and industries. In the present study sublethal concentration (12 mg.L -) of SiO‚‚ -NPs was exposed to the freshwater fish Oreochromis mossambicus (Peters 1852) for short-term (24 72 and 96 h) and long-term (15 30 and 60 days) durations maintaining a control group. Gill tissues showed significant (P 0.05) reduction in the activities of antioxidant enzymes superoxide dismutase catalase glutathione reductase and glutathione peroxidase with a concomitant increase in the production of hydrogen peroxide and lipid peroxidation. Liver tissue also showed induction of oxidative stress which was evident by the significant decrease in the activities of antioxidant enzymes and generation of hydrogen peroxide and lipid peroxidation. In brain tissue the alteration of antioxidant defence system was more prominent only after 96 h. The activities of tissue marker enzymes were also decreased in gill liver and brain tissues indicating tissue-specific nanotoxicity. The reversible of treatment for 60 days showed no withdrawal effect of nanoparticles in all tissues. The present results conclude that exposure to silicon dioxide nanoparticles induced oxidative stress and the effects are found irreversible in the gill liver and brain tissues of the fish O. mossambicus.

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Item Type:	Article
AGROVOC Term:	Oreochromis mossambicus
AGROVOC Term:	Freshwater fishes
AGROVOC Term:	Laboratory experimentation
AGROVOC Term:	Toxicity
AGROVOC Term:	Silicon
AGROVOC Term:	Dioxides
AGROVOC Term:	Gills
AGROVOC Term:	Liver
AGROVOC Term:	Brain
AGROVOC Term:	Animal tissues
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 06:29
URI:	http://webagris.upm.edu.my/id/eprint/24643

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