Chemical profile total phenolic content dpph free radical scavenging and alpha-glucosidase inhibitory activities of Cosmos caudatus kunth leaves


Citation

Azizah Abdul Hamid, . and Khozirah Shaari, . and Muhajir Hamid, . and Wan Nadilah Wan Ahmad, . and Alfi Khatib, . Chemical profile total phenolic content dpph free radical scavenging and alpha-glucosidase inhibitory activities of Cosmos caudatus kunth leaves. pp. 1367-1381. ISSN 1511-3701

Abstract

Herbs and medicinal plants are major sources of traditional or folk medicines for many countries of the world including Malaysia. This study evaluated the bioactive potential of the leaf ethanolic extract and solvent fractions of Cosmos Caudatus Kunth in scavenging free radicals and inhibiting the enzyme alpha-glucosidase. In addition their metabolite profiles were also characterized using liquid chromatography“mass spectrometry. The bioactivity was found to be concentrated in the EtOAc and BuOH fractions which largely contained rutin quercetin 3-O-galactoside quercetin 3-O-glucoside quercetin 3-O-xyloside quercetin 3-O-arabinofuranoside quercetin 3-O-rhamnoside and quercetin 3-O-galactoside as profiled by LC-MS/MS. It was further shown that the flavonoids glycosides contributed to the free radical scavenging and glucose lowering effects of C. caudatus leaves. The results indicated that the leaves of C. caudatus are a rich source of bioactive compounds and could be prospective materials for development of new anti-diabetic agents.


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Abstract

Herbs and medicinal plants are major sources of traditional or folk medicines for many countries of the world including Malaysia. This study evaluated the bioactive potential of the leaf ethanolic extract and solvent fractions of Cosmos Caudatus Kunth in scavenging free radicals and inhibiting the enzyme alpha-glucosidase. In addition their metabolite profiles were also characterized using liquid chromatography“mass spectrometry. The bioactivity was found to be concentrated in the EtOAc and BuOH fractions which largely contained rutin quercetin 3-O-galactoside quercetin 3-O-glucoside quercetin 3-O-xyloside quercetin 3-O-arabinofuranoside quercetin 3-O-rhamnoside and quercetin 3-O-galactoside as profiled by LC-MS/MS. It was further shown that the flavonoids glycosides contributed to the free radical scavenging and glucose lowering effects of C. caudatus leaves. The results indicated that the leaves of C. caudatus are a rich source of bioactive compounds and could be prospective materials for development of new anti-diabetic agents.

Additional Metadata

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Item Type: Article
AGROVOC Term: Medicinal herbs
AGROVOC Term: Medicinal plants
AGROVOC Term: Cosmos
AGROVOC Term: Asteraceae
AGROVOC Term: Leaves
AGROVOC Term: Plant extracts
AGROVOC Term: Solvent extraction
AGROVOC Term: Fractionation
AGROVOC Term: Alpha glucosidase
AGROVOC Term: Chemical properties
Depositing User: Ms. Suzila Mohamad Kasim
Last Modified: 24 Apr 2025 06:29
URI: http://webagris.upm.edu.my/id/eprint/24821

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