Subchronic toxicity of ethanolic extract velvet bean (Mucuna pruriens) from Indonesia

Sardjono Ratnaningsih Eko, . and Musthapa Iqbal, . and Sholihin, . and Khoerunnisa Fitri, . and Qowiyah Atun, . and Rachmawati Rahmi, . Subchronic toxicity of ethanolic extract velvet bean (Mucuna pruriens) from Indonesia. pp. 1497-1509. ISSN 1511-3701

The present study is aimed at investigating the subchronic toxicity of ethanol extract of Mucuna pruriens seeds from Indonesia. A total of 120 rats Wistar strain both sexes were used in this study. Both were divided into one control group three treated groups and two satellite groups. The extract in different doses was administered orally for 90 days for the treated groups while 120 days for the satellite groups. The subchronic toxicity was evaluated using various parameters including death motoric activity body weight haematology parameters biochemical parameters and organ weight along with the histopathological study. There was no mortality and no significant change in motoric activity body weight several haematological parameters and glucose levels. Significant differences were found in levels of cholesterol triglyceride AST and ALT BUN and creatinine. Degeneration of some tissues was seen in the kidneys and the liver. The ethanol extract of Mucuna pruriens seeds from Indonesia has a reversible subchronic toxicity to the liver and kidneys.

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Abstract

The present study is aimed at investigating the subchronic toxicity of ethanol extract of Mucuna pruriens seeds from Indonesia. A total of 120 rats Wistar strain both sexes were used in this study. Both were divided into one control group three treated groups and two satellite groups. The extract in different doses was administered orally for 90 days for the treated groups while 120 days for the satellite groups. The subchronic toxicity was evaluated using various parameters including death motoric activity body weight haematology parameters biochemical parameters and organ weight along with the histopathological study. There was no mortality and no significant change in motoric activity body weight several haematological parameters and glucose levels. Significant differences were found in levels of cholesterol triglyceride AST and ALT BUN and creatinine. Degeneration of some tissues was seen in the kidneys and the liver. The ethanol extract of Mucuna pruriens seeds from Indonesia has a reversible subchronic toxicity to the liver and kidneys.

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Item Type:	Article
AGROVOC Term:	Mucuna pruriens
AGROVOC Term:	Seeds
AGROVOC Term:	Extraction
AGROVOC Term:	Experimental design
AGROVOC Term:	Animals
AGROVOC Term:	Rats
AGROVOC Term:	Ethanol
AGROVOC Term:	Toxicity
AGROVOC Term:	Haematology
AGROVOC Term:	Histopathology
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 06:29
URI:	http://webagris.upm.edu.my/id/eprint/24832

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