Mammary gland tumours in the dog a spontaneous tumour model of comparative value to human breast cancer

Kabiru Sahabi, . and Sujey Kumar Rajendren, . and Foong Jia Ning, . and Gayathri Thevi Selvarajah, . Mammary gland tumours in the dog a spontaneous tumour model of comparative value to human breast cancer. pp. 541-574. ISSN 1511-3701

Mammary gland tumours are the most common neoplasia diagnosed in the female dog. These tumours occur spontaneously or naturally as in humans 50 of which are commonly diagnosed as malignant. Metastasis to other tissues especially the lung is a common cause of death in these dogs. Treatment of canine mammary gland tumours (CMT) involves mainly surgical resection with wide margin followed by chemotherapy with cytotoxic drugs for those with lymph node and distant metastasis. With the dog continuously described as a very suitable and valuable large animal model of human breast cancer it becomes very obvious that CMT can be a model to further understand the biology of cancer as well as screening for new therapeutic agents that could be used to treat human breast cancer and CMT more effectively. This review focuses on research work that has been done on CMT over the past years describing the epidemiology diagnostics and recent advances in therapy for CMT as well as discussing the significance of the dog CMT as spontaneous animal model for human breast cancer.

Full text available from: Official URL: http://www.pertanika.upm.edu.my/Pertanika%20PAPERS...

Abstract

Mammary gland tumours are the most common neoplasia diagnosed in the female dog. These tumours occur spontaneously or naturally as in humans 50 of which are commonly diagnosed as malignant. Metastasis to other tissues especially the lung is a common cause of death in these dogs. Treatment of canine mammary gland tumours (CMT) involves mainly surgical resection with wide margin followed by chemotherapy with cytotoxic drugs for those with lymph node and distant metastasis. With the dog continuously described as a very suitable and valuable large animal model of human breast cancer it becomes very obvious that CMT can be a model to further understand the biology of cancer as well as screening for new therapeutic agents that could be used to treat human breast cancer and CMT more effectively. This review focuses on research work that has been done on CMT over the past years describing the epidemiology diagnostics and recent advances in therapy for CMT as well as discussing the significance of the dog CMT as spontaneous animal model for human breast cancer.

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Item Type:	Article
AGROVOC Term:	Cancer (disease)
AGROVOC Term:	Mammary gland diseases
AGROVOC Term:	Animal tumours
AGROVOC Term:	Dogs
AGROVOC Term:	Surgical operations
AGROVOC Term:	Chemotherapy
AGROVOC Term:	Cytotoxicity
AGROVOC Term:	Animal models
AGROVOC Term:	Animal biology
AGROVOC Term:	Histopathology
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 06:29
URI:	http://webagris.upm.edu.my/id/eprint/24835

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