A mini review on phytochemical constituents and pharmacological activities of Adenium obesum

Chye S. M., . and Ling A. P. K., . and Koh R. Y., . and Mohamed Shafiq S., . and Lim C. L., . A mini review on phytochemical constituents and pharmacological activities of Adenium obesum. pp. 591-604. ISSN 1511-3701

Adenium obesum is a common plant found in many households in Malaysia. Its phytochemical constituents are believed to have contributed to its vast medicinal properties. Five types of compounds were isolated and identified from the plant namely cardiac glycosides pregnanes triterpenes flavonoids and carbohydrates. These compounds confer the plant its reported pharmacological activities such as antibacterial antiviral anticancer antioxidant immunomodulation and antiparasitic effects. The plants antibacterial effects against some bacterial strains such as Proteus mirabilis and Pseudomonas aeruginosa were investigated while its antiviral activity was tested against H1N1. Its anticancer activity was found to be mediated through the hedgehog/GLI signalling pathway. For the immunomodulatory effect A. obesum was found to promote proliferation of B and T cells. This review outlines in detail the pharmacological activities of A. obesum while further correlating these activities with the phytochemical constituents present.

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Abstract

Adenium obesum is a common plant found in many households in Malaysia. Its phytochemical constituents are believed to have contributed to its vast medicinal properties. Five types of compounds were isolated and identified from the plant namely cardiac glycosides pregnanes triterpenes flavonoids and carbohydrates. These compounds confer the plant its reported pharmacological activities such as antibacterial antiviral anticancer antioxidant immunomodulation and antiparasitic effects. The plants antibacterial effects against some bacterial strains such as Proteus mirabilis and Pseudomonas aeruginosa were investigated while its antiviral activity was tested against H1N1. Its anticancer activity was found to be mediated through the hedgehog/GLI signalling pathway. For the immunomodulatory effect A. obesum was found to promote proliferation of B and T cells. This review outlines in detail the pharmacological activities of A. obesum while further correlating these activities with the phytochemical constituents present.

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Item Type:	Article
AGROVOC Term:	Apocynaceae
AGROVOC Term:	Flowering plants
AGROVOC Term:	Medicinal properties
AGROVOC Term:	Pharmacology
AGROVOC Term:	Phytochemistry
AGROVOC Term:	Chemical compounds
AGROVOC Term:	Cardiac glycosides
AGROVOC Term:	Flavonoids
AGROVOC Term:	Carbohydrates
AGROVOC Term:	Antiviral agents
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 06:29
URI:	http://webagris.upm.edu.my/id/eprint/24837

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