Di-isononyl phthalate (DINP) impairs reproduction in the freshwater fish Oreochromis mossambicus (Peters 1852)

Revathy V., . and Chitra K. C., . Di-isononyl phthalate (DINP) impairs reproduction in the freshwater fish Oreochromis mossambicus (Peters 1852). pp. 284-296. ISSN 0116-6514

Phthalates the plasticisers widely used to improve the characteristics of polyvinyl chloride products are frequently released into the environment causing severe health hazards. Reproductive toxicity of phthalate plasticisers in aquatic organisms is of major concern. Therefore the present study was aimed to examine the role of di-isononyl phthalate (DINP) on reproductive impairment in Oreochromis mossambicus(Peters 1852). DINP at 300 ppm (mg L-1) concentration was exposed to fish for short-term (24 48 72 and 96 h) and long-term (7 14 30 and 60 days) durations. After the treatment period the activities of superoxide dismutase catalase glutathione reductase and glutathione peroxidase were evaluated in the ovary and testis. The level of lipid peroxidation along with the steroidogenic enzyme activities namely 3- and 17-hydroxysteroid dehydrogenase was also observed. A significant (P 0.05) decrease in the activities of all antioxidant enzymes with a concomitant increase in the level of lipid peroxidation was noted in both ovary and testis. The inhibitory effect of DINP on antioxidant enzymes increases with time indicating the induction of oxidative stress in gonads. Besides the activities of steroidogenic enzymes decreased significantly (P 0.05) demonstrating that DINP altered the normal ovarian and testicular steroidogenesis thereby impairs reproduction of fish.

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Abstract

Phthalates the plasticisers widely used to improve the characteristics of polyvinyl chloride products are frequently released into the environment causing severe health hazards. Reproductive toxicity of phthalate plasticisers in aquatic organisms is of major concern. Therefore the present study was aimed to examine the role of di-isononyl phthalate (DINP) on reproductive impairment in Oreochromis mossambicus(Peters 1852). DINP at 300 ppm (mg L-1) concentration was exposed to fish for short-term (24 48 72 and 96 h) and long-term (7 14 30 and 60 days) durations. After the treatment period the activities of superoxide dismutase catalase glutathione reductase and glutathione peroxidase were evaluated in the ovary and testis. The level of lipid peroxidation along with the steroidogenic enzyme activities namely 3- and 17-hydroxysteroid dehydrogenase was also observed. A significant (P 0.05) decrease in the activities of all antioxidant enzymes with a concomitant increase in the level of lipid peroxidation was noted in both ovary and testis. The inhibitory effect of DINP on antioxidant enzymes increases with time indicating the induction of oxidative stress in gonads. Besides the activities of steroidogenic enzymes decreased significantly (P 0.05) demonstrating that DINP altered the normal ovarian and testicular steroidogenesis thereby impairs reproduction of fish.

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Item Type:	Article
AGROVOC Term:	Oreochromis mossambicus
AGROVOC Term:	Freshwater fishes
AGROVOC Term:	Phthalates
AGROVOC Term:	Propylene glycol
AGROVOC Term:	Sampling
AGROVOC Term:	Environmental control
AGROVOC Term:	Chlorinated water
AGROVOC Term:	Laboratory experimentation
AGROVOC Term:	Animal reproductive organs
AGROVOC Term:	Oxidative stress
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 06:29
URI:	http://webagris.upm.edu.my/id/eprint/24926

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