Biological properties and chemical diversity of Sinularia flexibilis an alcyonacean soft coral

Thilahgavani Nagappan, . and Kishneth Palaniveloo, . Biological properties and chemical diversity of Sinularia flexibilis an alcyonacean soft coral. pp. 15-33. ISSN 1823-8556

Soft corals of the genus Sinularia (order Alcyonacea) are one of the most widespread sessile organisms in the Indo-Pacific waters. Unlike the hard corals the major portion of soft coral is made up of inorganic skeletons consisting of calcareous spicules surrounded by a thin layer of tissue. This layer of tissue made up of fleshy colonies with organic matter is responsible in diversity of secondary metabolites. In order to survive the outburst of algal bloom dynamic of microbial growth and predation of marine organisms these soft corals synthesize unique chemicals as part of defense mechanism that makes them unpalatable to most marine life. As such members of the genus Sinularia exhibits a diversity of secondary metabolites ranging from sesquiterpenes diterpenes polyhydroxylated steroids and polyamine compounds. These metabolites had been shown to possess various biological activities such as antimicrobial anti-inflammatory and cytotoxicity. This present paper reviews the chemistry and highlights the potential biological activities of metabolites from Sinularia flexibilis and provides a perspective for future research.

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Abstract

Soft corals of the genus Sinularia (order Alcyonacea) are one of the most widespread sessile organisms in the Indo-Pacific waters. Unlike the hard corals the major portion of soft coral is made up of inorganic skeletons consisting of calcareous spicules surrounded by a thin layer of tissue. This layer of tissue made up of fleshy colonies with organic matter is responsible in diversity of secondary metabolites. In order to survive the outburst of algal bloom dynamic of microbial growth and predation of marine organisms these soft corals synthesize unique chemicals as part of defense mechanism that makes them unpalatable to most marine life. As such members of the genus Sinularia exhibits a diversity of secondary metabolites ranging from sesquiterpenes diterpenes polyhydroxylated steroids and polyamine compounds. These metabolites had been shown to possess various biological activities such as antimicrobial anti-inflammatory and cytotoxicity. This present paper reviews the chemistry and highlights the potential biological activities of metabolites from Sinularia flexibilis and provides a perspective for future research.

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Item Type:	Article
AGROVOC Term:	Corals
AGROVOC Term:	Biological properties
AGROVOC Term:	Chemical composition
AGROVOC Term:	Secondary metabolites
AGROVOC Term:	Predation
AGROVOC Term:	Diterpenes
AGROVOC Term:	Steroids
AGROVOC Term:	Polyamines
AGROVOC Term:	Antimicrobials
AGROVOC Term:	Antiinflammatory agents
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 06:29
URI:	http://webagris.upm.edu.my/id/eprint/25008

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