Probiotic strains as adjuvants in Helicobacter pylori treatment: a review

Boyanova, L. Y. and Boyanova, L. and Yordanov, D. V. and Gergova,, R. T. and Markovska, R. D. (2025) Probiotic strains as adjuvants in Helicobacter pylori treatment: a review. International Food Research Journal (Malaysia), 32. pp. 28-40. ISSN 2231 7546

Eradicating Helicobacter pylori infection has become increasingly difficult over time, mainly due to rising antibiotic resistance and unsatisfactory patient compliance. Lactobacilli, which taxonomy was revised in 2020 splitting the genus Lactobacillus into 24 genera, are frequently used as probiotics. According to the majority of recent studies, probiotics promote faster recovery of antibiotic-associated dysbacteriosis, and significantly reduce the adverse effects of eradication therapy. Some studies revealed a slight increase in H. pylori eradication. Other studies, however, showed only a transient H. pylori inhibition, suggesting that the period for testing eradication success should be extended from one to at least two months. Since most probiotics are bacteria, they may be inhibited by antibiotics to some extent. Moreover, they can participate in horizontal gene transfer, spreading antibiotic resistance. Therefore, we suggest that probiotic fungi be administered during the eradication therapy, followed by a transition to probiotic lactobacilli afterwards. Lactobacilli temporarily suppress virulent H. pylori strains, with bacteriocin production of the strains being an additional advantage. Further evaluation of synergistic or antagonistic effects of probiotic combinations is needed. New probiotics such as Pediococcus spp. and Clostridium butyricum should also be evaluated.

Full text available from: Official URL: http://www.ifrj.upm.edu.my/32%20(01)%202025/02%20-...

Abstract

Eradicating Helicobacter pylori infection has become increasingly difficult over time, mainly due to rising antibiotic resistance and unsatisfactory patient compliance. Lactobacilli, which taxonomy was revised in 2020 splitting the genus Lactobacillus into 24 genera, are frequently used as probiotics. According to the majority of recent studies, probiotics promote faster recovery of antibiotic-associated dysbacteriosis, and significantly reduce the adverse effects of eradication therapy. Some studies revealed a slight increase in H. pylori eradication. Other studies, however, showed only a transient H. pylori inhibition, suggesting that the period for testing eradication success should be extended from one to at least two months. Since most probiotics are bacteria, they may be inhibited by antibiotics to some extent. Moreover, they can participate in horizontal gene transfer, spreading antibiotic resistance. Therefore, we suggest that probiotic fungi be administered during the eradication therapy, followed by a transition to probiotic lactobacilli afterwards. Lactobacilli temporarily suppress virulent H. pylori strains, with bacteriocin production of the strains being an additional advantage. Further evaluation of synergistic or antagonistic effects of probiotic combinations is needed. New probiotics such as Pediococcus spp. and Clostridium butyricum should also be evaluated.

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Item Type:	Article
AGROVOC Term:	probiotics
AGROVOC Term:	treatment date
AGROVOC Term:	Helicobacter pylori
AGROVOC Term:	antibiotics
AGROVOC Term:	Fungi
AGROVOC Term:	antibiotic resistance genes
AGROVOC Term:	Clostridium butyricum
AGROVOC Term:	bacteriocins
Geographical Term:	Bulgaria
Depositing User:	Nor Hasnita Abdul Samat
Date Deposited:	16 Mar 2026 03:13
Last Modified:	16 Mar 2026 03:13
URI:	http://webagris.upm.edu.my/id/eprint/25108

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