Antidiabetic potential and antioxidant effect of aqueous and ethanolic extracts obtained from soursop (Annona muricata L.) seeds and peels

Sosa-Crespo, I. and Mugarte-Moguel, A. and Chel-Guerrero, L. and Rodríguez-Canto, W. and Betancur-Ancona, D. (2025) Antidiabetic potential and antioxidant effect of aqueous and ethanolic extracts obtained from soursop (Annona muricata L.) seeds and peels. International Food Research Journal (Malaysia), 32. pp. 195-207. ISSN 2231 7546

Currently, large quantities of fruit residues like soursop peels and seeds, which could be used to obtain bioactive compounds with applications in traditional medicine due to their potential benefits, are discarded. Therefore, the aim of the present work was to evaluate the inhibitory effect on carbohydrate metabolism enzymes, and the antioxidant activity of aqueous extracts from soursop (Annona muricata L.) peels and seeds, for their potential application as nutraceuticals or functional food ingredients. The peels and seeds were obtained as wastes from pulp extraction, and processed to obtain aqueous and ethanolic extracts. The inhibitory effects of extracts on α-amylase and α-glucosidase were evaluated. The total phenolic content was determined by the Folin-Ciocalteu method, and the antioxidant capacity was evaluated with DPPH (2, 2'-diphenyl-1-picrylhydrazyl) and ABTS+ (2,2´-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid). Phenolic compounds were also identified by HPLC. The inhibitory effect of the aqueous extract of peels was 92.80% for α-amylase, and 91.22% for α-glucosidase, while the ethanolic extract of peels presented a total phenolic content of 0.0576 mg GAE/mg. The sample with the highest antioxidant capacity for DPPH and ABTS+ was the aqueous extract of peels, which showed the presence of 26 phenolic compounds, including gallic acid, vanillic acid, ferulic acid, and catechin. Overall, soursop peels could have antioxidant and glycosidic metabolism benefits, offering an alternative use to the inedible parts of the fruit for potential use in the formulation of functional foods.

Full text available from: Official URL: http://www.ifrj.upm.edu.my/32%20(01)%202025/14%20-...

Abstract

Currently, large quantities of fruit residues like soursop peels and seeds, which could be used to obtain bioactive compounds with applications in traditional medicine due to their potential benefits, are discarded. Therefore, the aim of the present work was to evaluate the inhibitory effect on carbohydrate metabolism enzymes, and the antioxidant activity of aqueous extracts from soursop (Annona muricata L.) peels and seeds, for their potential application as nutraceuticals or functional food ingredients. The peels and seeds were obtained as wastes from pulp extraction, and processed to obtain aqueous and ethanolic extracts. The inhibitory effects of extracts on α-amylase and α-glucosidase were evaluated. The total phenolic content was determined by the Folin-Ciocalteu method, and the antioxidant capacity was evaluated with DPPH (2, 2'-diphenyl-1-picrylhydrazyl) and ABTS+ (2,2´-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid). Phenolic compounds were also identified by HPLC. The inhibitory effect of the aqueous extract of peels was 92.80% for α-amylase, and 91.22% for α-glucosidase, while the ethanolic extract of peels presented a total phenolic content of 0.0576 mg GAE/mg. The sample with the highest antioxidant capacity for DPPH and ABTS+ was the aqueous extract of peels, which showed the presence of 26 phenolic compounds, including gallic acid, vanillic acid, ferulic acid, and catechin. Overall, soursop peels could have antioxidant and glycosidic metabolism benefits, offering an alternative use to the inedible parts of the fruit for potential use in the formulation of functional foods.

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Item Type:	Article
AGROVOC Term:	extraction
AGROVOC Term:	phenolic compounds
AGROVOC Term:	antioxidants
AGROVOC Term:	functional foods
AGROVOC Term:	HPLC
Geographical Term:	Mexico
Depositing User:	Nor Hasnita Abdul Samat
Date Deposited:	16 Mar 2026 03:38
Last Modified:	16 Mar 2026 03:38
URI:	http://webagris.upm.edu.my/id/eprint/25118

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