Nephrotoxicity effect of Ginseng Bugis (Talinum paniculatum (Jacq) Gaertn) leaves ethanolic extract on creatinine, urea, and kidney histopathological features

Emelda A., . and Santi I., . and Besse S. C. D., . and Aderafni A., . and Yuliana D., . (2024) Nephrotoxicity effect of Ginseng Bugis (Talinum paniculatum (Jacq) Gaertn) leaves ethanolic extract on creatinine, urea, and kidney histopathological features. International Food Research Journal (Malaysia), 31. pp. 417-422. ISSN 2231 7546

The prolonged use of traditional medicines in large doses is known to potentially cause organ failure, with the kidneys being particularly susceptible. Therefore, the present work aimed to determine the effect of Talinum paniculatum (Jacq.) Gaertn leaves ethanolic extract on serum creatinine and urea parameters, as well as kidney histopathological features, in an animal model. The rats used were separated into four groups. Group I (control) was given Na-CMC 1% (w/v); while groups II, III, and IV were administered ethanolic extract of Ginseng Bugis leaves at doses of 0.8, 1.6, and 2.4 g/kg bw, respectively. The extract was induced orally for 28 days, while the serum creatinine and urea levels were measured using human analyser on days 0 and 29. Additionally, a necropsy for organ retrieval of the kidneys was conducted on day 15. Tissue processing was then carried out for histopathological examination by Haematoxylin Eosin (HE) staining. Based on One way ANOVA statistical analysis on creatinine and urea levels, ethanolic extract of Ginseng Bugis leaves at doses of 0.8, 1.6, and 2.4 g/kg bw had no nephrotoxic effects. Regarding the histopathological features of the kidneys, the dose of 0.8 g/kg bw caused no abnormalities.

Full text available from: Official URL: http://www.ifrj.upm.edu.my/31%20(02)%202024/12%20-...

Abstract

The prolonged use of traditional medicines in large doses is known to potentially cause organ failure, with the kidneys being particularly susceptible. Therefore, the present work aimed to determine the effect of Talinum paniculatum (Jacq.) Gaertn leaves ethanolic extract on serum creatinine and urea parameters, as well as kidney histopathological features, in an animal model. The rats used were separated into four groups. Group I (control) was given Na-CMC 1% (w/v); while groups II, III, and IV were administered ethanolic extract of Ginseng Bugis leaves at doses of 0.8, 1.6, and 2.4 g/kg bw, respectively. The extract was induced orally for 28 days, while the serum creatinine and urea levels were measured using human analyser on days 0 and 29. Additionally, a necropsy for organ retrieval of the kidneys was conducted on day 15. Tissue processing was then carried out for histopathological examination by Haematoxylin Eosin (HE) staining. Based on One way ANOVA statistical analysis on creatinine and urea levels, ethanolic extract of Ginseng Bugis leaves at doses of 0.8, 1.6, and 2.4 g/kg bw had no nephrotoxic effects. Regarding the histopathological features of the kidneys, the dose of 0.8 g/kg bw caused no abnormalities.

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Item Type:	Article
AGROVOC Term:	Panax ginseng
AGROVOC Term:	medicinal plants
AGROVOC Term:	plant extracts
AGROVOC Term:	kidneys
AGROVOC Term:	laboratory equipment
AGROVOC Term:	toxicity tests
AGROVOC Term:	histopathology
AGROVOC Term:	urea
AGROVOC Term:	health
Geographical Term:	Indonesia
Uncontrolled Keywords:	Talinum paniculatum, nephrotoxic, creatinine, urea, histopathological
Depositing User:	Nor Hasnita Abdul Samat
Date Deposited:	23 Feb 2026 03:54
Last Modified:	23 Feb 2026 03:54
URI:	http://webagris.upm.edu.my/id/eprint/2594

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