Citation
Le, Q. U. and Lanh, T. N. (2024) Inhibitory capacity of xanthine oxidase, and anticancer activity of compounds from Sarcandra glabra (Thunb.) Nakai flower. International Food Research Journal (Malaysia), 31. pp. 637-646. ISSN 2231 7546
Abstract
The flower of Sarcandra glabra (Thunb.) Nakai (FSN) has been considered an important supplementation material in natural flower-flavoured tea products in Vietnam. The present work has considerable significance for adding pharmacological value of FSN. Two compounds, namely emodin and methyl rosmarinate, were identified for the first time from a methanolic extract of FSN from Vietnam while analysing the inhibitory capacity of xanthine oxidase and cytotoxic activities. High levels of xanthine oxidase inhibiting capacity and cytotoxicity activity against HepG2 and A549 cancer cell lines were detected from emodin, with IC50 of 4.88 ± 0.42, 13.72 ± 0.48, and 18.33 ± 0.10 µg/mL, respectively. Emodin also activated the apoptotic factors of caspase-9, Bax, and PARP in HepG2, and caspase-3/9 and p53 in A549. Our results revealed for the first time the xanthine oxidase inhibitory effect of M70 with IC50 of 34.15 ± 1.33 µg/mL, which would shed light on its potential application for developing anti-hyperuricemia agents. The present work suggested that using flower-flavoured tea product of FSN could have many health benefits for gout patients.
Download File
Full text available from:
Official URL: http://www.ifrj.upm.edu.my/31%20(03)%202024/09%20-...
|
Abstract
The flower of Sarcandra glabra (Thunb.) Nakai (FSN) has been considered an important supplementation material in natural flower-flavoured tea products in Vietnam. The present work has considerable significance for adding pharmacological value of FSN. Two compounds, namely emodin and methyl rosmarinate, were identified for the first time from a methanolic extract of FSN from Vietnam while analysing the inhibitory capacity of xanthine oxidase and cytotoxic activities. High levels of xanthine oxidase inhibiting capacity and cytotoxicity activity against HepG2 and A549 cancer cell lines were detected from emodin, with IC50 of 4.88 ± 0.42, 13.72 ± 0.48, and 18.33 ± 0.10 µg/mL, respectively. Emodin also activated the apoptotic factors of caspase-9, Bax, and PARP in HepG2, and caspase-3/9 and p53 in A549. Our results revealed for the first time the xanthine oxidase inhibitory effect of M70 with IC50 of 34.15 ± 1.33 µg/mL, which would shed light on its potential application for developing anti-hyperuricemia agents. The present work suggested that using flower-flavoured tea product of FSN could have many health benefits for gout patients.
Additional Metadata
| Item Type: | Article |
|---|---|
| AGROVOC Term: | flowers |
| AGROVOC Term: | tea |
| AGROVOC Term: | extraction |
| AGROVOC Term: | emodin |
| AGROVOC Term: | xanthine oxidase |
| AGROVOC Term: | cytotoxicity |
| AGROVOC Term: | apoptosis |
| AGROVOC Term: | gout |
| AGROVOC Term: | medicinal plants |
| AGROVOC Term: | medicinal properties |
| Geographical Term: | Vietnam |
| Uncontrolled Keywords: | gout, emodin, Sarcandra glabra flower, xanthine oxidase, flower-flavoured tea |
| Depositing User: | Nor Hasnita Abdul Samat |
| Date Deposited: | 23 Feb 2026 04:17 |
| Last Modified: | 23 Feb 2026 04:17 |
| URI: | http://webagris.upm.edu.my/id/eprint/2623 |
Actions (login required)
 |
View Item |
