The effects of Aquilaria malaccensis leaf extracts on blood glucose level, kidney profile and liver function in streptozotocin induced diabetic rats

Zulkifle N. L., . and Shaari M. R, . and Omar N. A. M., . and Tajuddin S. N., . (2024) The effects of Aquilaria malaccensis leaf extracts on blood glucose level, kidney profile and liver function in streptozotocin induced diabetic rats. Journal of Tropical Agriculture and Food Science (Malaysia), 52 (1). pp. 105-111. ISSN 1394-9829

Diabetes mellitus is clinically defined as hyperglycemia or an abnormality caused due to increased glucose intake and a disordered metabolism. Aquilaria malaccensis has been shown its beneficial effects in reduction of postprandial glucose intake. Overall, the aim of this study was to evaluate the antidiabetic effects of A. malaccensis methanolic and aqueous leaf extracts on Streptozotocin-induced (STZ-induced) diabetic rats.The STZ-induced diabetic rat model was used to compare the effect of 500 mg/kg A. malaccensis methanolic and aqueous leaf extracts on blood glucose levels as compared to the standard drug 500 mg/kg metformin. Treatment with A. malaccensis methanolic and aqueous leaves extracts of 500 mg/kg body weight for 5 days resulted in a significant (p <0.05) decrease in blood glucose level, with percentage of glucose lowering effects of 57.08% and 55.48%, respectively, compared to metformin, which showed a percentage of glucose lowering effects of 68.79%. Furthermore, the biochemical parameters assessment on diabetic rats treated with both extracts showed that the extract did not enhance damage in serum protein. This could suggest that the extracts did not cause any significant damage in the internal organs such as liver and kidneys. These findings indicated that A. malaccensis methanolic and aqueous extracts have the potential to lower blood glucose levels without causing harm to the animals and could be used as a supplementary food in the management of diabetes mellitus.

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Abstract

Diabetes mellitus is clinically defined as hyperglycemia or an abnormality caused due to increased glucose intake and a disordered metabolism. Aquilaria malaccensis has been shown its beneficial effects in reduction of postprandial glucose intake. Overall, the aim of this study was to evaluate the antidiabetic effects of A. malaccensis methanolic and aqueous leaf extracts on Streptozotocin-induced (STZ-induced) diabetic rats.The STZ-induced diabetic rat model was used to compare the effect of 500 mg/kg A. malaccensis methanolic and aqueous leaf extracts on blood glucose levels as compared to the standard drug 500 mg/kg metformin. Treatment with A. malaccensis methanolic and aqueous leaves extracts of 500 mg/kg body weight for 5 days resulted in a significant (p <0.05) decrease in blood glucose level, with percentage of glucose lowering effects of 57.08% and 55.48%, respectively, compared to metformin, which showed a percentage of glucose lowering effects of 68.79%. Furthermore, the biochemical parameters assessment on diabetic rats treated with both extracts showed that the extract did not enhance damage in serum protein. This could suggest that the extracts did not cause any significant damage in the internal organs such as liver and kidneys. These findings indicated that A. malaccensis methanolic and aqueous extracts have the potential to lower blood glucose levels without causing harm to the animals and could be used as a supplementary food in the management of diabetes mellitus.

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Item Type:	Article
AGROVOC Term:	medicinal plants
AGROVOC Term:	diabetes
AGROVOC Term:	leaf extracts
AGROVOC Term:	animal models
AGROVOC Term:	pharmacology
AGROVOC Term:	functional foods
AGROVOC Term:	biochemical composition
Geographical Term:	Malaysia
Depositing User:	Ms. Azariah Hashim
Date Deposited:	20 Nov 2025 08:56
Last Modified:	20 Nov 2025 08:56
URI:	http://webagris.upm.edu.my/id/eprint/2676

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