Supplementation of Chlorella vulgaris ameliorates the stress-induced hematological alterations in Wistar rats


Citation

Mulyati, . and Syariatin, Lasmini, . and Sofyantoro, Fajar, . (2024) Supplementation of Chlorella vulgaris ameliorates the stress-induced hematological alterations in Wistar rats. Pertanika Journal Tropical Agricultural Science (Malaysia), 47 (1). pp. 131-146. ISSN 1511-3701

Abstract

Stress has been associated with various diseases and physiological disruptions. Chlorella vulgaris is known for its antioxidant properties. This study examined the effects of C. vulgaris on the hematological profile of stress-induced Wistar rats. Stress significantly impacted various hematological parameters, including erythrocyte count, hemoglobin concentration, hematocrit levels, white blood cell count, and platelet count. The supplementation of cultivated C. vulgaris effectively restored erythrocyte count and suppressed elevated lymphocyte levels, while commercially available C. vulgaris and amitriptyline drugs had no significant effects on these parameters. Stress caused smaller-sized erythrocytes but did not significantly affect mean corpuscular volume. Both amitriptyline and C. vulgaris restored platelet levels, while mean platelet volume remained unaffected. Overall, C. vulgaris showed promise as a therapeutic intervention for countering stress-induced inhibition of erythropoiesis and restoring erythrocyte count, but more research is needed to understand the underlying mechanisms and develop effective strategies for managing stress-related changes in hematological parameters.


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Abstract

Stress has been associated with various diseases and physiological disruptions. Chlorella vulgaris is known for its antioxidant properties. This study examined the effects of C. vulgaris on the hematological profile of stress-induced Wistar rats. Stress significantly impacted various hematological parameters, including erythrocyte count, hemoglobin concentration, hematocrit levels, white blood cell count, and platelet count. The supplementation of cultivated C. vulgaris effectively restored erythrocyte count and suppressed elevated lymphocyte levels, while commercially available C. vulgaris and amitriptyline drugs had no significant effects on these parameters. Stress caused smaller-sized erythrocytes but did not significantly affect mean corpuscular volume. Both amitriptyline and C. vulgaris restored platelet levels, while mean platelet volume remained unaffected. Overall, C. vulgaris showed promise as a therapeutic intervention for countering stress-induced inhibition of erythropoiesis and restoring erythrocyte count, but more research is needed to understand the underlying mechanisms and develop effective strategies for managing stress-related changes in hematological parameters.

Additional Metadata

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Item Type: Article
AGROVOC Term: Chlorella vulgaris
AGROVOC Term: stress
AGROVOC Term: antioxidants
AGROVOC Term: rats
AGROVOC Term: haematology
AGROVOC Term: erythrocytes
AGROVOC Term: erythropoiesis
AGROVOC Term: drug therapy
Geographical Term: Indonesia
Depositing User: Ms. Azariah Hashim
Date Deposited: 21 Nov 2025 08:56
Last Modified: 21 Nov 2025 08:56
URI: http://webagris.upm.edu.my/id/eprint/2727

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