Developmental toxicity of zinc oxide nanoparticles on the early life stage of Java Medaka (Oryzias javanicus Bleeker, 1856)

Amin, Naweedullah and Vedi, Farida and Navid Wais, Mohammad and Syaizwan Zahmir Zulkifli, . and Mohammad Noor Amal Azmai, . and Ahmad Ismail, . (2024) Developmental toxicity of zinc oxide nanoparticles on the early life stage of Java Medaka (Oryzias javanicus Bleeker, 1856). Pertanika Journal Tropical Agricultural Science (Malaysia), 47 (2). 575 -590. ISSN 1511-3701

With a high likelihood of being discharged into aquatic habitats, zinc oxide nanoparticles have been widely employed in a variety of industrial and commercial goods. Concerns over their effects on the environment and human health have grown. This study evaluated the developmental toxicity of zinc oxide nanoparticles (ZnO NPs) on the embryo Java medaka (Oryzias javanicus). With three replicates for each treatment group, the Java medaka embryos were subject to various concentrations of ZnO NPs (10, 25, 50, 100, and 150 μg/L). The heartbeat of treated embryos was increased compared to the control group at 5-, 8-, and 11-days post-exposure (dpe). However, the hatching and mortality of embryos decreased when the concentrations of ZnO NPs increased. Meanwhile, deformities such as low pigmentation, edema (yolk sac and pericardial edema), and spinal deformities were observed in the embryo and larva during the exposure time. Compared to previous studies, ZnO NPs show severe toxicity to selected endpoints at lower concentrations in the embryos of Java medaka.

Full text available from: Official URL: http://www.pertanika.upm.edu.my/resources/files/Pe...

Abstract

With a high likelihood of being discharged into aquatic habitats, zinc oxide nanoparticles have been widely employed in a variety of industrial and commercial goods. Concerns over their effects on the environment and human health have grown. This study evaluated the developmental toxicity of zinc oxide nanoparticles (ZnO NPs) on the embryo Java medaka (Oryzias javanicus). With three replicates for each treatment group, the Java medaka embryos were subject to various concentrations of ZnO NPs (10, 25, 50, 100, and 150 μg/L). The heartbeat of treated embryos was increased compared to the control group at 5-, 8-, and 11-days post-exposure (dpe). However, the hatching and mortality of embryos decreased when the concentrations of ZnO NPs increased. Meanwhile, deformities such as low pigmentation, edema (yolk sac and pericardial edema), and spinal deformities were observed in the embryo and larva during the exposure time. Compared to previous studies, ZnO NPs show severe toxicity to selected endpoints at lower concentrations in the embryos of Java medaka.

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Item Type:	Article
AGROVOC Term:	fish
AGROVOC Term:	nanoparticles
AGROVOC Term:	eggs
AGROVOC Term:	exposure tolerance
AGROVOC Term:	plant embryos
AGROVOC Term:	larvae
AGROVOC Term:	hatching
AGROVOC Term:	mortality
Geographical Term:	Malaysia
Uncontrolled Keywords:	Early life stage, Medaka, nanoparticles, ZnO NPs
Depositing User:	Ms. Azariah Hashim
Date Deposited:	19 Mar 2026 02:30
Last Modified:	19 Mar 2026 02:30
URI:	http://webagris.upm.edu.my/id/eprint/2939

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