Red snapper fish intake improves thyroid gland activity in the hypothyroidism rat

Herawati E., . and Titisari R.S., . and Husna S.A.N., . and Astirin O.P., . and Widiyani T., . and Listyawati S., . (2021) Red snapper fish intake improves thyroid gland activity in the hypothyroidism rat. Food Research (Malaysia), 5 (S2). pp. 18-24. ISSN 2550-2166

Congenital hypothyroidism is inadequate production of thyroid hormone in infants from birth. Treatment of hypothyroidism often involves an iodine-rich diet since iodine is a vital precursor for thyroid hormone synthesis. Red snapper fish is a saltwater fish that contain a high amount of iodine and other beneficial macro/micronutrients, yet no report was found on the effect of this fish consumption on hypothyroidism. The objective of this study was to determine the effectiveness of red snapper (Lutjanus sp.) fish on thyroid gland activity, manifested by low FT4 level and high TSH level, two diagnostic indicators of hypothyroidism. This study used a post-test and controlled group design. Pregnant female rats were given propylthiouracil orally for four weeks to induce hypothyroidism in their offspring. All hypothyroid offspring were divided into five treatment groups, i.e., negative control, positive control (thyroxin therapy), red snapper enriched diet at 25% and 50% dosage, also a combination of levothyroxine and red snapper. The thyroid gland activity was detected by measuring blood serum FT4 and TSH and histological examination of the thyroid gland using HE staining. The level of FT4 and TSH in each treatment group were analyzed with the one-way ANOVA test. The results showed that the group that received a 50% red snapper diet has a normal level of FT4 and TSH, whereas the FT4 level increased two-fold; the TSH level decreased significantly. The organization of the thyroid gland showed a remarkable change of the lumen diameter, indicating a higher amount of hormone production by the gland.

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Abstract

Congenital hypothyroidism is inadequate production of thyroid hormone in infants from birth. Treatment of hypothyroidism often involves an iodine-rich diet since iodine is a vital precursor for thyroid hormone synthesis. Red snapper fish is a saltwater fish that contain a high amount of iodine and other beneficial macro/micronutrients, yet no report was found on the effect of this fish consumption on hypothyroidism. The objective of this study was to determine the effectiveness of red snapper (Lutjanus sp.) fish on thyroid gland activity, manifested by low FT4 level and high TSH level, two diagnostic indicators of hypothyroidism. This study used a post-test and controlled group design. Pregnant female rats were given propylthiouracil orally for four weeks to induce hypothyroidism in their offspring. All hypothyroid offspring were divided into five treatment groups, i.e., negative control, positive control (thyroxin therapy), red snapper enriched diet at 25% and 50% dosage, also a combination of levothyroxine and red snapper. The thyroid gland activity was detected by measuring blood serum FT4 and TSH and histological examination of the thyroid gland using HE staining. The level of FT4 and TSH in each treatment group were analyzed with the one-way ANOVA test. The results showed that the group that received a 50% red snapper diet has a normal level of FT4 and TSH, whereas the FT4 level increased two-fold; the TSH level decreased significantly. The organization of the thyroid gland showed a remarkable change of the lumen diameter, indicating a higher amount of hormone production by the gland.

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Item Type:	Article
Additional Information:	The 3rd International Conference on Food Science and Engineering (ICFSE) 2020
AGROVOC Term:	fish
AGROVOC Term:	diet
AGROVOC Term:	therapy
AGROVOC Term:	hypothyroidism
AGROVOC Term:	thyroid gland
AGROVOC Term:	iodine
AGROVOC Term:	rats
AGROVOC Term:	physiological response
Geographical Term:	Indonesia
Depositing User:	Mr. Khoirul Asrimi Md Nor
Date Deposited:	04 Feb 2026 08:48
Last Modified:	04 Feb 2026 08:48
URI:	http://webagris.upm.edu.my/id/eprint/3212

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