Association between prolactin receptor (PRLR) gene polymorphisms and litter size in Katjang-Boer hybrid goats

Poh, J. L. and Mohd NoorHisham M. N., . and Nurulhuda M. O., . and Noor Athirah A., . and Mohd Firdaus O., . and Ainu Husna M. S. S., . (2024) Association between prolactin receptor (PRLR) gene polymorphisms and litter size in Katjang-Boer hybrid goats. Malaysian Journal of Animal Science (Malaysia), 27 (1). pp. 20-31. ISSN 2550-2123

Goat fertility is essential for farm productivity and economic viability. This study investigates the association between Prolactin Receptor (PRLR) gene polymorphism and litter size in Katjang-Boer hybrid goats. DNA from 43 goats was analyzed using five primers targeting different regions of the PRLR gene. Polymerase chain reaction (PCR) and Single-Strand Conformation Polymorphism (SSCP) were employed to detect genetic variation. The association between litter size, breeding year, and PRLR polymorphism was determined using Kruskal-Wallis and Mann-Whitney U tests. Results indicate a significant association between PRLR gene polymorphisms in intron 1 and intron 2 with litter size (p < 0.05). Specifically, the AH genotype in intron 1 was significantly associated with larger litter sizes (1.58 ± 0.19, p < 0.05). No significant associations were found for exon 9 and 3<UTR regions. Breeding year also significantly influenced litter size, with the highest numbers observed in the later parity. These findings provide insights for improving farm productivity through genetic selection.

Full text available from: Official URL: https://mjas.my/mjas-v2/rf/pages/journal/v27i1/2.%...

Abstract

Goat fertility is essential for farm productivity and economic viability. This study investigates the association between Prolactin Receptor (PRLR) gene polymorphism and litter size in Katjang-Boer hybrid goats. DNA from 43 goats was analyzed using five primers targeting different regions of the PRLR gene. Polymerase chain reaction (PCR) and Single-Strand Conformation Polymorphism (SSCP) were employed to detect genetic variation. The association between litter size, breeding year, and PRLR polymorphism was determined using Kruskal-Wallis and Mann-Whitney U tests. Results indicate a significant association between PRLR gene polymorphisms in intron 1 and intron 2 with litter size (p < 0.05). Specifically, the AH genotype in intron 1 was significantly associated with larger litter sizes (1.58 ± 0.19, p < 0.05). No significant associations were found for exon 9 and 3<UTR regions. Breeding year also significantly influenced litter size, with the highest numbers observed in the later parity. These findings provide insights for improving farm productivity through genetic selection.

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Item Type:	Article
AGROVOC Term:	goats
AGROVOC Term:	genes
AGROVOC Term:	goat breeds
AGROVOC Term:	fertility
AGROVOC Term:	PCR
AGROVOC Term:	molecular genetics
AGROVOC Term:	reproduction
AGROVOC Term:	litter size
Geographical Term:	Malaysia
Depositing User:	Ms. Azariah Hashim
Date Deposited:	29 Jul 2026 02:42
Last Modified:	29 Jul 2026 02:42
URI:	http://webagris.upm.edu.my/id/eprint/3549

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