Potential hypocholesterolemic activity of flour from leaves of moringa (Moringa oleifera L.)

Asrifah Indah, . and Estiasih Teti, . and Sujuti Hidayat, . Potential hypocholesterolemic activity of flour from leaves of moringa (Moringa oleifera L.). pp. 449-460. ISSN 1394-035X

Moringa (Moringa oleifera L.) leaves contain phytosterols and dietary fibres which may be beneficial in controlling blood cholesterol levels. This study was aimed at assessing the hypocholesterolemic effect of flour from leaves of M. oleifera L. (MLF) with white and red stalk in rats. Methods: Thirty male rats were divided into 6 groups comprising a normal group (negative control) a hypercholestrolemic group (positive control) both of which were without MLF feeding and 4 hypercholesterolemic groups fed MLF for 4 weeks in the following manner: (i) 0.822 mg/g bw/d white stalk (WM); (ii) 0.822 mg/g bw/d red stalk (RM); (iii) 0.02 ml/g bw/d commercial plant stanol ester (FS); and (iv) 0.001 mg/g bw/d ezetimibe (ET). At the end serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-c) viscosity and pH of digesta faecal cholesterol and short chain fatty acids (SCFAs) were analysed. Results: TC levels in the WM RM FS and ET groups decreased by 42.0 48.8 48.4 and 52.8 respectively compared to initial levels. The four groups also showed decreases in serum LDL-c levels by 30.3 39.2 37.9 and 46.7 respectively over the feeding period. Faecal cholesterol levels of WM and RM were higher (63.931.87 and 90.111.77 mg/100 g faeces respectively) than that of the positive control (51.304.03 mg/100 g) after 4 weeks. Conclusion: Flour from moringa leaves of white and red stalk trees showed potential hypocholesterolemic activity in rats.

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Abstract

Moringa (Moringa oleifera L.) leaves contain phytosterols and dietary fibres which may be beneficial in controlling blood cholesterol levels. This study was aimed at assessing the hypocholesterolemic effect of flour from leaves of M. oleifera L. (MLF) with white and red stalk in rats. Methods: Thirty male rats were divided into 6 groups comprising a normal group (negative control) a hypercholestrolemic group (positive control) both of which were without MLF feeding and 4 hypercholesterolemic groups fed MLF for 4 weeks in the following manner: (i) 0.822 mg/g bw/d white stalk (WM); (ii) 0.822 mg/g bw/d red stalk (RM); (iii) 0.02 ml/g bw/d commercial plant stanol ester (FS); and (iv) 0.001 mg/g bw/d ezetimibe (ET). At the end serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-c) viscosity and pH of digesta faecal cholesterol and short chain fatty acids (SCFAs) were analysed. Results: TC levels in the WM RM FS and ET groups decreased by 42.0 48.8 48.4 and 52.8 respectively compared to initial levels. The four groups also showed decreases in serum LDL-c levels by 30.3 39.2 37.9 and 46.7 respectively over the feeding period. Faecal cholesterol levels of WM and RM were higher (63.931.87 and 90.111.77 mg/100 g faeces respectively) than that of the positive control (51.304.03 mg/100 g) after 4 weeks. Conclusion: Flour from moringa leaves of white and red stalk trees showed potential hypocholesterolemic activity in rats.

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Item Type:	Article
AGROVOC Term:	Moringa
AGROVOC Term:	Moringa oleifera
AGROVOC Term:	Hypercholesterolaemia
AGROVOC Term:	Cholesterol
AGROVOC Term:	Blood lipids
AGROVOC Term:	Leaves
AGROVOC Term:	Flours
AGROVOC Term:	Phytosterols
AGROVOC Term:	Fibres
AGROVOC Term:	Centrifuging
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:53
URI:	http://webagris.upm.edu.my/id/eprint/7736

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