Citation
Hasrini Reno Fitri, . and Zakaria Fransiska Rungkat, . and Adawiyah Dede Robiatul, . and Suparto Irma Herawati, . Antidiabetic and immunomodulatory potential of purple soymilk enriched with crude palm oil microcapsule in type- 2 diabetes mellitus respondents. pp. 461-471. ISSN 1394-035X
Abstract
Purple soymilk produced from black soybean has been reported to reduce fasting blood glucose (FBG) and HbA1c of type 2 diabetes mellitus (T2DM) patients. Crude palm oil (CPO) is known to have immunomodulatory activity. This study aimed to investigate the antidiabetic and immunomodulatory potential of purple soymilk enriched with CPO microcapsule (PSPOM) in T2DM respondents. Methods: A total of 25 T2DM patients from Katili clinic and Bogor Agricultural University Indonesia were recruited by purposive cluster sampling and divided into control and test groups. The test group consumed PSPOM made up of 240 mL of purple soymilk with 0.4 g CPO microcapsule containing 295.24 g carotenoid/g capsule daily for 4 weeks. Blood sample of 2 mL was collected from each subject before and after the intervention. Dietary intakes were assessed using the 24-h food recall method. Results: When compared between the start and end of the intervention the test group showed significant mean decreases in fasting blood glucose from 177.20 93.55 to 154.87 71.13 mg/dL and in HbA1c from 0.29 0.07 to 0.26 0.06 OD450. The test group also showed a mean increase of IL-6 level from 0.23 0.04 to 0.25 0.06 OD450 and significant increases in the level of insulin from 0.18 0.05 to 0.21 0.07 OD450 over the same duration. Results also showed increases of CD4 from 563.13 194.62 to 679.95 278.86 cell/L blood and CD8 T cells from 317.91 105.40 to 343.74 162.27 86 cell/L blood during the intervention period. Conclusion: Consumption of PSPOM in this study showed potential antidiabetic and immunomodulatory activities in T2DM respondents. Further studies should be undertaken to confirm these results.
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Abstract
Purple soymilk produced from black soybean has been reported to reduce fasting blood glucose (FBG) and HbA1c of type 2 diabetes mellitus (T2DM) patients. Crude palm oil (CPO) is known to have immunomodulatory activity. This study aimed to investigate the antidiabetic and immunomodulatory potential of purple soymilk enriched with CPO microcapsule (PSPOM) in T2DM respondents. Methods: A total of 25 T2DM patients from Katili clinic and Bogor Agricultural University Indonesia were recruited by purposive cluster sampling and divided into control and test groups. The test group consumed PSPOM made up of 240 mL of purple soymilk with 0.4 g CPO microcapsule containing 295.24 g carotenoid/g capsule daily for 4 weeks. Blood sample of 2 mL was collected from each subject before and after the intervention. Dietary intakes were assessed using the 24-h food recall method. Results: When compared between the start and end of the intervention the test group showed significant mean decreases in fasting blood glucose from 177.20 93.55 to 154.87 71.13 mg/dL and in HbA1c from 0.29 0.07 to 0.26 0.06 OD450. The test group also showed a mean increase of IL-6 level from 0.23 0.04 to 0.25 0.06 OD450 and significant increases in the level of insulin from 0.18 0.05 to 0.21 0.07 OD450 over the same duration. Results also showed increases of CD4 from 563.13 194.62 to 679.95 278.86 cell/L blood and CD8 T cells from 317.91 105.40 to 343.74 162.27 86 cell/L blood during the intervention period. Conclusion: Consumption of PSPOM in this study showed potential antidiabetic and immunomodulatory activities in T2DM respondents. Further studies should be undertaken to confirm these results.
Additional Metadata
Item Type: | Article |
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AGROVOC Term: | Glycine soja |
AGROVOC Term: | Soy milk |
AGROVOC Term: | Soya beans |
AGROVOC Term: | Crude oil |
AGROVOC Term: | Palm oils |
AGROVOC Term: | Diabetes |
AGROVOC Term: | Diabetes mellitus |
AGROVOC Term: | Mixing |
AGROVOC Term: | Fasting |
AGROVOC Term: | Blood glucose |
Depositing User: | Mr. AFANDI ABDUL MALEK |
Last Modified: | 24 Apr 2025 00:53 |
URI: | http://webagris.upm.edu.my/id/eprint/7737 |
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