Double salt fortification with iodine and iron: An in vivo study on albino rat

Khan M. I., . and Anjum F. M., . and Iahtisham-Ul-Haq, . and Sultan S., . and Butt M. S., . and Suleria H. A. R., . Double salt fortification with iodine and iron: An in vivo study on albino rat. pp. 255-262. ISSN 2231-7546

Iron iodine and vitamin A deficiencies are major clinical conditions affecting 33 of global population. Dual fortification of salt with iron and iodine could be a sustainable approach to fight against Iron Deficiency Anaemia (IDA) and Iodine Deficiency Disorders (IDD). The present work was designed to analyse the bioavailability of iron and iodine fortificants. For this reason common table salt (NaCl) was subjected to various analyses like moisture ash and minerals followed by double salt fortification with iron compounds like sodium iron ethylene diamine tetra acetate (NaFeEDTA) iron(II) sulphate (FeSO4) and potassium iodate (KIO3) at two different levels. Bioavailability of iron and iodine fortificants was analysed by feeding albino rats with fortified salt at 3.5. Serum thyroxin (T4) level increased significantly from day 0 to 28 (26.72 0.2 to 31.41 0.4 nmol/L). Haemoglobin (Hb) and serum ferritin levels also depicted significant increase with the passage of time. However whole blood zinc protoporphyrin serum transferrin and serum triiodothyronine significantly decreased. As a conclusion the present work revealed that double fortification of salt with iron and iodine along with a suitable stabiliser could be an effective strategy to control the two major micronutrient deficiencies.

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Abstract

Iron iodine and vitamin A deficiencies are major clinical conditions affecting 33 of global population. Dual fortification of salt with iron and iodine could be a sustainable approach to fight against Iron Deficiency Anaemia (IDA) and Iodine Deficiency Disorders (IDD). The present work was designed to analyse the bioavailability of iron and iodine fortificants. For this reason common table salt (NaCl) was subjected to various analyses like moisture ash and minerals followed by double salt fortification with iron compounds like sodium iron ethylene diamine tetra acetate (NaFeEDTA) iron(II) sulphate (FeSO4) and potassium iodate (KIO3) at two different levels. Bioavailability of iron and iodine fortificants was analysed by feeding albino rats with fortified salt at 3.5. Serum thyroxin (T4) level increased significantly from day 0 to 28 (26.72 0.2 to 31.41 0.4 nmol/L). Haemoglobin (Hb) and serum ferritin levels also depicted significant increase with the passage of time. However whole blood zinc protoporphyrin serum transferrin and serum triiodothyronine significantly decreased. As a conclusion the present work revealed that double fortification of salt with iron and iodine along with a suitable stabiliser could be an effective strategy to control the two major micronutrient deficiencies.

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Item Type:	Article
AGROVOC Term:	Iron
AGROVOC Term:	Iodine
AGROVOC Term:	Bioavailability
AGROVOC Term:	Table salt
AGROVOC Term:	Food fortification
AGROVOC Term:	Potassium
AGROVOC Term:	Sodium
AGROVOC Term:	In vivo experimentation
AGROVOC Term:	Rats
AGROVOC Term:	Analytical methods
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:53
URI:	http://webagris.upm.edu.my/id/eprint/7784

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