Saffron extract and crocin reduced biomarkers associated with obesity in rats fed a high-fat diet

Barakatun Nisak Mohd Yusof, . and Azrina Azlan, . and Huzwah Khaza'ai, . and Maryam Mashmoul, . and Norhafizah Mohtarrudin, . Saffron extract and crocin reduced biomarkers associated with obesity in rats fed a high-fat diet. pp. 117-127. ISSN 1394-035X

Introduction: This study aimed to investigate the effect of saffron extract and crocin on blood biomarkers associated with obesity using the rat model. Methods: Obesity was induced by feeding a high-fat diet to 42 male Sprague-Dawley rats for 12 weeks after which they were equally distributed into seven groups. Three groups served as controls namely normal diet (ND) high-fat diet (HFD) and high-fat diet plus orlistat (HFD ORL) while the remaining four treatment groups consisted of HFD added low or high dose (40 and 80 mg/kg/day) of either saffron extract or crocin in the food. At the end of 8 weeks blood samples were collected by cardiac puncture for biochemical analysis. Results: Obese rats treated with a high dose of saffron extract and crocin showed significantly lower plasma glucose levels (5.26 and 5.67 mmol/L respectively) than the HFD rats (6.92 mmol/L). Saffron extract and crocin at a high dose showed significantly lower levels of plasma insulin (3.97 and 3.88 ng/mL respctively) compared to HFD control (5.41 ng/mL). Adiponectin levels significantly increased in obese rats fed saffron extract and crocin at high doses (7.44 and 7.92 g/mL respectively) compared to HFD control (5.34 g/mL). Ghrelin level significantly increased from 419.10 to 284.10 pg/mL while leptin level significantly decreased from 8.08 to 5.68 ng/mL for the high dose crocin groups compared to HFD control. No significant differences in plasma serotonin levels were found among the groups. Conclusion : Saffron extract and crocin show potential in reducing blood biomarkers associated with obesity as well as anti-inflammatory and regulatory potential of adipocytokines in an animal model.

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Abstract

Introduction: This study aimed to investigate the effect of saffron extract and crocin on blood biomarkers associated with obesity using the rat model. Methods: Obesity was induced by feeding a high-fat diet to 42 male Sprague-Dawley rats for 12 weeks after which they were equally distributed into seven groups. Three groups served as controls namely normal diet (ND) high-fat diet (HFD) and high-fat diet plus orlistat (HFD ORL) while the remaining four treatment groups consisted of HFD added low or high dose (40 and 80 mg/kg/day) of either saffron extract or crocin in the food. At the end of 8 weeks blood samples were collected by cardiac puncture for biochemical analysis. Results: Obese rats treated with a high dose of saffron extract and crocin showed significantly lower plasma glucose levels (5.26 and 5.67 mmol/L respectively) than the HFD rats (6.92 mmol/L). Saffron extract and crocin at a high dose showed significantly lower levels of plasma insulin (3.97 and 3.88 ng/mL respctively) compared to HFD control (5.41 ng/mL). Adiponectin levels significantly increased in obese rats fed saffron extract and crocin at high doses (7.44 and 7.92 g/mL respectively) compared to HFD control (5.34 g/mL). Ghrelin level significantly increased from 419.10 to 284.10 pg/mL while leptin level significantly decreased from 8.08 to 5.68 ng/mL for the high dose crocin groups compared to HFD control. No significant differences in plasma serotonin levels were found among the groups. Conclusion : Saffron extract and crocin show potential in reducing blood biomarkers associated with obesity as well as anti-inflammatory and regulatory potential of adipocytokines in an animal model.

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Item Type:	Article
AGROVOC Term:	Crocus sativus
AGROVOC Term:	Biochemical markers
AGROVOC Term:	Biochemistry
AGROVOC Term:	Animal models
AGROVOC Term:	Blood
AGROVOC Term:	Blood sampling
AGROVOC Term:	Extraction
AGROVOC Term:	Diet
AGROVOC Term:	Feeding
AGROVOC Term:	Food intake
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:53
URI:	http://webagris.upm.edu.my/id/eprint/7823

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