Relationship between vitamin D PTH and insulin resistance in the development of non-alcoholic fatty liver disease (NAFLD)

Jamali H., . and Ebrahimi-Mameghani M., . and Abedi R. S., . and Kabir M. B., . and Khoshbaten M., . Relationship between vitamin D PTH and insulin resistance in the development of non-alcoholic fatty liver disease (NAFLD). pp. 325-334. ISSN 1394-035X

Introduction: Vitamin D plays an important role in the regulation of several genes associated with metabolic disorders. This study was designed to investigate the relationship between serum 25 (OH) D and parathyroid hormone (PTH) levels and insulin resistance in patients with non-alcoholic fatty liver disease (NAFLD). Methods: A case-control study was carried out among patients with NAFLD (n 80) as cases and age-matched subjects without NAFLD (n 80) as controls. After 8-12 h of fasting serum 25 (OH) D insulin and PTH levels were assessed using Enzyme-Linked Immunosorbent Assay (ELISA) technique. Multivariate logistic regression model was applied to assess the relationship between vitamin D and PTH and insulin resistance in the development of NAFLD by adjusting for the confounders (sex BMI and waist-to-hip ratio). Results: There was no significant difference in sunlight exposure between the two groups (p 0.274). Patients with NAFLD had significantly lower serum 25(OH) D levels and higher PTH levels compared to subjects without NAFLD (p0.001). The association between NAFLD and low 25(OH) vitamin D levels was independent of confounders (adjusted OR: 8.78 CI 95:1.71 45.03). Homeostatic Model Assessment Insulin Resistance (HOMA-IR) as insulin resistance index was significantly high in the NAFLD group (adjusted OR: 1.80 CI 95: 1.32 2.47). Conclusion : Our findings showed that lower serum 25 (OH) D levels and higher HOMA indices were independently associated with increased odds of NAFLD and there was a direct but not significant relationship between PTH serum levels and the risk of NAFLD.

Full text available from: Official URL: http://www.nutriweb.org.my/mjn/publication/22-4/a....

Abstract

Introduction: Vitamin D plays an important role in the regulation of several genes associated with metabolic disorders. This study was designed to investigate the relationship between serum 25 (OH) D and parathyroid hormone (PTH) levels and insulin resistance in patients with non-alcoholic fatty liver disease (NAFLD). Methods: A case-control study was carried out among patients with NAFLD (n 80) as cases and age-matched subjects without NAFLD (n 80) as controls. After 8-12 h of fasting serum 25 (OH) D insulin and PTH levels were assessed using Enzyme-Linked Immunosorbent Assay (ELISA) technique. Multivariate logistic regression model was applied to assess the relationship between vitamin D and PTH and insulin resistance in the development of NAFLD by adjusting for the confounders (sex BMI and waist-to-hip ratio). Results: There was no significant difference in sunlight exposure between the two groups (p 0.274). Patients with NAFLD had significantly lower serum 25(OH) D levels and higher PTH levels compared to subjects without NAFLD (p0.001). The association between NAFLD and low 25(OH) vitamin D levels was independent of confounders (adjusted OR: 8.78 CI 95:1.71 45.03). Homeostatic Model Assessment Insulin Resistance (HOMA-IR) as insulin resistance index was significantly high in the NAFLD group (adjusted OR: 1.80 CI 95: 1.32 2.47). Conclusion : Our findings showed that lower serum 25 (OH) D levels and higher HOMA indices were independently associated with increased odds of NAFLD and there was a direct but not significant relationship between PTH serum levels and the risk of NAFLD.

[error in script]

Item Type:	Article
AGROVOC Term:	Fatty liver
AGROVOC Term:	Liver diseases
AGROVOC Term:	Metabolic disorders
AGROVOC Term:	Case studies
AGROVOC Term:	Anthropometry
AGROVOC Term:	Body mass
AGROVOC Term:	Body measurements
AGROVOC Term:	Fasting
AGROVOC Term:	Genes
AGROVOC Term:	Height
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:53
URI:	http://webagris.upm.edu.my/id/eprint/7849

Actions (login required)

View Item