Comparing the effectiveness of oral supplementation and intramuscular injection of Vitamin B12 for treating cobalamin deficiency: systematic review and meta-analysis


Citation

Lee Kyung Eun, . and Park Hyo Jin, . and Cui Yinghua, . Comparing the effectiveness of oral supplementation and intramuscular injection of Vitamin B12 for treating cobalamin deficiency: systematic review and meta-analysis. pp. 317-323. ISSN 1394-035X

Abstract

Introduction: The common treatments for vitamin B‚�‚‚ (Vit. B‚�‚‚) deficiency are oral supplementation (OS) and intramuscular (IM) injection. However there have been debates on which treatment is more effective. Therefore this analysis is aimed at comparing the effectiveness of OS and IM injection using systematic review and meta-analysis. Methods: A search was undertaken in the Cochrane Library MEDLINE EMBASE and KoreaMed for randomised controlled trials (RCTs) on the study subject. We included papers that compared OS and IM injection methods for vitamin B12 treatment for cobalamin deficient patients. Changes in vitamin B12 serum levels before and after the treatments were compared. SPSS program version 18.0 and Review Manager 5.2 were used. Results: The search revealed only three appropriate studies for our analysis involving a total of 141 patients out of whom 66 were given OS and 75 IM injection. The standardised mean difference (SMD) between OS and IM injection was 0.14 (95 CI -0.20 0.48 p 0.42). In considering tolerability adverse events and cost OS was found to be better than IM injection. Conclusions: OS is recommended over IM injection for Vit. B‚�‚‚ treatment method.


Download File

Full text available from:

Abstract

Introduction: The common treatments for vitamin B‚�‚‚ (Vit. B‚�‚‚) deficiency are oral supplementation (OS) and intramuscular (IM) injection. However there have been debates on which treatment is more effective. Therefore this analysis is aimed at comparing the effectiveness of OS and IM injection using systematic review and meta-analysis. Methods: A search was undertaken in the Cochrane Library MEDLINE EMBASE and KoreaMed for randomised controlled trials (RCTs) on the study subject. We included papers that compared OS and IM injection methods for vitamin B12 treatment for cobalamin deficient patients. Changes in vitamin B12 serum levels before and after the treatments were compared. SPSS program version 18.0 and Review Manager 5.2 were used. Results: The search revealed only three appropriate studies for our analysis involving a total of 141 patients out of whom 66 were given OS and 75 IM injection. The standardised mean difference (SMD) between OS and IM injection was 0.14 (95 CI -0.20 0.48 p 0.42). In considering tolerability adverse events and cost OS was found to be better than IM injection. Conclusions: OS is recommended over IM injection for Vit. B‚�‚‚ treatment method.

Additional Metadata

[error in script]
Item Type: Article
AGROVOC Term: Cobalamin
AGROVOC Term: Intramuscular injection
AGROVOC Term: Injection
AGROVOC Term: Data analysis
AGROVOC Term: Nutrition
AGROVOC Term: Methodology
AGROVOC Term: Application methods
AGROVOC Term: Research
AGROVOC Term: Techniques
AGROVOC Term: Vitamins
Depositing User: Mr. AFANDI ABDUL MALEK
Last Modified: 24 Apr 2025 00:53
URI: http://webagris.upm.edu.my/id/eprint/7875

Actions (login required)

View Item View Item
Agris UPM is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.