Association between isoflavones consumption and cognitive function and comorbidities among older adults residing in the state of Johor Malaysia

Bibi Nabihah A. H., . and Suzana S., . and Hasnah H., . Association between isoflavones consumption and cognitive function and comorbidities among older adults residing in the state of Johor Malaysia. pp. 29-39. ISSN 1394-035X

Introduction: This two-phase longitudinal study sought to determine the association between isoflavones intake on cognitive function and comorbidities among older adults from the state of Johor Malaysia. Methods: Phase I involved baseline data collection to examine the association between isoflavones intake and cognitive function among 400 respondents aged 60-years and above recruited through multistage random sampling. Phase 2 determined the association between isoflavones intake at the baseline and comorbidities at an 18-month follow-up. The baseline data collected included information on socio-demographics health status andunpometric measurements and dietary intake using a dietary history questionnaire (DHQ). Each participant's cognitive function was evaluated using a mini mental state examination (MMSE) digit span digit symbol and geriatric depression scale (GDS). Results: The daily intake of total isoflavones daidzein and genistein were 19.119.7 11.712.3 and 7.68.1 mg/day respectively. There was no significant association between isoflavones intake and specific cognitive function including global memory executive functions and depression. However there was a significant association (p0.05) between isoflavones intake r0.131 (95 CI: 0.064-0.199) daidzein intake r0.132 (95 CI: 0.064-0.199) and genistein intake r0.129 (95 CI: 0.062-0.197) with memory (digit span) after adjustment for age gender educational level and body mass index (11M1). No association was found between isoflavones intake and comorbidities (p0.05). Conclusion: This study found an association between isoflavones intake and memory function but not with global cognitive executive functions depression and comorbidities. There is a need to promote adequate isoflavones intake in view of its association with memory function.

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Abstract

Introduction: This two-phase longitudinal study sought to determine the association between isoflavones intake on cognitive function and comorbidities among older adults from the state of Johor Malaysia. Methods: Phase I involved baseline data collection to examine the association between isoflavones intake and cognitive function among 400 respondents aged 60-years and above recruited through multistage random sampling. Phase 2 determined the association between isoflavones intake at the baseline and comorbidities at an 18-month follow-up. The baseline data collected included information on socio-demographics health status andunpometric measurements and dietary intake using a dietary history questionnaire (DHQ). Each participant's cognitive function was evaluated using a mini mental state examination (MMSE) digit span digit symbol and geriatric depression scale (GDS). Results: The daily intake of total isoflavones daidzein and genistein were 19.119.7 11.712.3 and 7.68.1 mg/day respectively. There was no significant association between isoflavones intake and specific cognitive function including global memory executive functions and depression. However there was a significant association (p0.05) between isoflavones intake r0.131 (95 CI: 0.064-0.199) daidzein intake r0.132 (95 CI: 0.064-0.199) and genistein intake r0.129 (95 CI: 0.062-0.197) with memory (digit span) after adjustment for age gender educational level and body mass index (11M1). No association was found between isoflavones intake and comorbidities (p0.05). Conclusion: This study found an association between isoflavones intake and memory function but not with global cognitive executive functions depression and comorbidities. There is a need to promote adequate isoflavones intake in view of its association with memory function.

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Item Type:	Article
AGROVOC Term:	Isoflavones
AGROVOC Term:	Daidzein
AGROVOC Term:	Genistein
AGROVOC Term:	Elderly
AGROVOC Term:	Anthropometry
AGROVOC Term:	Body mass
AGROVOC Term:	Body measurements
AGROVOC Term:	Random sampling
AGROVOC Term:	Data collection
AGROVOC Term:	Evaluation
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:53
URI:	http://webagris.upm.edu.my/id/eprint/7878

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