Association between serum B12 and folate levels and manifestations of oral lesions in HIV adult patients

Puspasari Dewi, . and Diah Herawati Dewi Marhaeni, . and Sufiawati Irna, . Association between serum B12 and folate levels and manifestations of oral lesions in HIV adult patients. pp. 507-513. ISSN 1394-035X

Introduction : Micronutrient deficiencies are common in Human Immunodeficiency Virus (HIV) infection. The long-term side effects of antiretroviral therapy (ART) specifically Azidothymine (AZT) include low serum levels of vitamin B‚�‚‚ and folate which in turn lead to megaloblastic anaemia and oral lesions. Methods : A crosssectional study was conducted to determine the associations between manifestation of oral lesions and serum vitamin B‚�‚‚ and folate levels in HIV-adult patients with or without receiving ART therapy. Oral lesions were determined based on the ECClearinghouse diagnostic criteria. Serum vitamin B‚�‚‚ and folate were assessed by electrochemiluminescence immunoassay (ECLIA). Sixty participants (48 males and 12 females) aged 20 to 51 years were recruited from a private hospital in Bandung Indonesia. Results : Subnormal levels of serum vitamin B‚�‚‚ and folate were found in 16.6 and 6.7 HIV patients respectively. Significantly lower serum levels of vitamin B‚�‚‚ and folate were shown in HIV patients receiving ART than those without ART. Oral lesions were found in all the participants with subnormal levels of serum vitamin B‚�‚‚ and folate. Presence of oral lesions was significantly associated with low levels of serum vitamin B‚�‚‚ in HIV patients with ART but not with low folate levels. Conclusion : Low levels of serum vitamin B‚�‚‚ and folate were shown in HIV patients indicating the need for early nutritional intervention to ensure optimal nutritional status and prevention of oral lesions in HIV patients

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Abstract

Introduction : Micronutrient deficiencies are common in Human Immunodeficiency Virus (HIV) infection. The long-term side effects of antiretroviral therapy (ART) specifically Azidothymine (AZT) include low serum levels of vitamin B‚�‚‚ and folate which in turn lead to megaloblastic anaemia and oral lesions. Methods : A crosssectional study was conducted to determine the associations between manifestation of oral lesions and serum vitamin B‚�‚‚ and folate levels in HIV-adult patients with or without receiving ART therapy. Oral lesions were determined based on the ECClearinghouse diagnostic criteria. Serum vitamin B‚�‚‚ and folate were assessed by electrochemiluminescence immunoassay (ECLIA). Sixty participants (48 males and 12 females) aged 20 to 51 years were recruited from a private hospital in Bandung Indonesia. Results : Subnormal levels of serum vitamin B‚�‚‚ and folate were found in 16.6 and 6.7 HIV patients respectively. Significantly lower serum levels of vitamin B‚�‚‚ and folate were shown in HIV patients receiving ART than those without ART. Oral lesions were found in all the participants with subnormal levels of serum vitamin B‚�‚‚ and folate. Presence of oral lesions was significantly associated with low levels of serum vitamin B‚�‚‚ in HIV patients with ART but not with low folate levels. Conclusion : Low levels of serum vitamin B‚�‚‚ and folate were shown in HIV patients indicating the need for early nutritional intervention to ensure optimal nutritional status and prevention of oral lesions in HIV patients

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Item Type:	Article
AGROVOC Term:	Serum therapy
AGROVOC Term:	Vitamin B12
AGROVOC Term:	HIV
AGROVOC Term:	patients
AGROVOC Term:	Cross sectional analysis
AGROVOC Term:	Nutritional supplements
AGROVOC Term:	Lesions
AGROVOC Term:	Anaemia
AGROVOC Term:	Nutritional status
AGROVOC Term:	oral
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:54
URI:	http://webagris.upm.edu.my/id/eprint/8028

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