Citation
Boligon A. A., . and Olawuyi A. D., . and Olasupo F., . and Irondi A. E., . and Lawal B. S., . and Olalekan S. I., . Comparative inhibitory effects of cocoa bean and cocoa pod husk extracts on enzymes associated with hyperuricemia and hypertension in vitro. pp. 557-564. ISSN 2231-7546
Abstract
Cocoa (Theobroma cacao L.) bean and its products have numerous health benefits. However the pod husk is generally regarded as waste. In the present work the inhibitory effects of cocoa bean powder (CBP) and cocoa pod husk powder (CPHP) extracts on enzymes associated with hyperuricemia (xanthine oxidase XO) and hypertension (angiotensin 1-converting enzyme ACE) were comparatively investigated in vitro. Free radicals scavenging abilities and phenolic constituents of the extracts were also determined. CBP significantly inhibited XO and ACE and scavenged 2 2-diphenyl-2-picrylhydrazyl radical (DPPH) more than the CPHP; but their 2 2-azinobis (3-ethyl-benzothiazoline-6-sulfonic acid) radical cation (ABTS ) scavenging potentials were insignificantly different. Phenolic acids (gallic chlorogenic and caffeic acids) and flavonoids (quercitrin quercetin and apigenin) were detected in both extracts. The levels of gallic and chlorogenic acids and apigenin were significantly higher in the CBP than in the CPHP; whereas their levels of caffeic acids quercitrin and quercetin were insignificantly different. Hence both CBP and CPHP might be useful for the treatment of hyperuricemia and hypertension through the inhibition of XO and ACE and scavenging of free radicals. However CBP might be more effective than CPHP due to its stronger enzymes inhibitory potentials and higher levels of certain phenolic compounds.
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Abstract
Cocoa (Theobroma cacao L.) bean and its products have numerous health benefits. However the pod husk is generally regarded as waste. In the present work the inhibitory effects of cocoa bean powder (CBP) and cocoa pod husk powder (CPHP) extracts on enzymes associated with hyperuricemia (xanthine oxidase XO) and hypertension (angiotensin 1-converting enzyme ACE) were comparatively investigated in vitro. Free radicals scavenging abilities and phenolic constituents of the extracts were also determined. CBP significantly inhibited XO and ACE and scavenged 2 2-diphenyl-2-picrylhydrazyl radical (DPPH) more than the CPHP; but their 2 2-azinobis (3-ethyl-benzothiazoline-6-sulfonic acid) radical cation (ABTS ) scavenging potentials were insignificantly different. Phenolic acids (gallic chlorogenic and caffeic acids) and flavonoids (quercitrin quercetin and apigenin) were detected in both extracts. The levels of gallic and chlorogenic acids and apigenin were significantly higher in the CBP than in the CPHP; whereas their levels of caffeic acids quercitrin and quercetin were insignificantly different. Hence both CBP and CPHP might be useful for the treatment of hyperuricemia and hypertension through the inhibition of XO and ACE and scavenging of free radicals. However CBP might be more effective than CPHP due to its stronger enzymes inhibitory potentials and higher levels of certain phenolic compounds.
Additional Metadata
Item Type: | Article |
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AGROVOC Term: | Theobroma |
AGROVOC Term: | Theobroma cacao |
AGROVOC Term: | Malvaceae |
AGROVOC Term: | Cocoa beans |
AGROVOC Term: | Extracts |
AGROVOC Term: | Inhibition |
AGROVOC Term: | Enzymes |
AGROVOC Term: | Xanthine oxidase |
AGROVOC Term: | Hypertension |
AGROVOC Term: | In vitro |
Depositing User: | Mr. AFANDI ABDUL MALEK |
Last Modified: | 24 Apr 2025 00:54 |
URI: | http://webagris.upm.edu.my/id/eprint/8082 |
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