Evaluation of DPPH free radical scavenging -glucosidase inhibitory and antimicrobial activities of Aquilaria malaccensis leaf extracts

Abdul Manaf Ali, . and Wan Nadilah Adibah Wan Ahmad, . and Wan Nur Amalina Wan Mamat, . and Nor Hasima Mahmod, . Evaluation of DPPH free radical scavenging -glucosidase inhibitory and antimicrobial activities of Aquilaria malaccensis leaf extracts. pp. 36-45. ISSN 2231-7546

Herbs and medicinal plants are major ingredients in traditional or folk medicine for many countries of the world including Malaysia. This study evaluated the potential of the leaf extract in different solvent polarities and drying methods of Aquilaria malaccensis in scavenging free radicals and inhibiting the enzyme -glucosidase as well as antimicrobial activities. Both methanol and ethanol extracts in oven dry method were efficient solvents to extract the antioxidant constituents of A. malaccensis. To analyze -glucosidase inhibitory activity the methanol extracts of A. malaccensis in air dry method exhibited the highest activity with an IC‚‚ value of 196.31 g/mL. In addition for the antimicrobial activity each extract was tested by a serial two-fold dilution method against selected Gram-positive bacteria and Gram-negative bacteria and this suggested that hexane in oven dry method possessed the maximum antimicrobial activity against the gram-positive bacteria tested. It is suggested that the antioxidant and antidiabetic properties were exhibited most in a polar solvent (MEOH) whether in air dry or oven dry method with no significant difference. In contrary with antimicrobial which was efficient in a non-polar solvent (HEX) in oven dry method. These results indicate that A. malaccensis is a promising source as herbal medicine.

Full text available from: Official URL: https://journal.unisza.edu.my/agrobiotechnology/in...

Abstract

Herbs and medicinal plants are major ingredients in traditional or folk medicine for many countries of the world including Malaysia. This study evaluated the potential of the leaf extract in different solvent polarities and drying methods of Aquilaria malaccensis in scavenging free radicals and inhibiting the enzyme -glucosidase as well as antimicrobial activities. Both methanol and ethanol extracts in oven dry method were efficient solvents to extract the antioxidant constituents of A. malaccensis. To analyze -glucosidase inhibitory activity the methanol extracts of A. malaccensis in air dry method exhibited the highest activity with an IC‚‚ value of 196.31 g/mL. In addition for the antimicrobial activity each extract was tested by a serial two-fold dilution method against selected Gram-positive bacteria and Gram-negative bacteria and this suggested that hexane in oven dry method possessed the maximum antimicrobial activity against the gram-positive bacteria tested. It is suggested that the antioxidant and antidiabetic properties were exhibited most in a polar solvent (MEOH) whether in air dry or oven dry method with no significant difference. In contrary with antimicrobial which was efficient in a non-polar solvent (HEX) in oven dry method. These results indicate that A. malaccensis is a promising source as herbal medicine.

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Item Type:	Article
AGROVOC Term:	Thymelaeaceae
AGROVOC Term:	Medicinal plants
AGROVOC Term:	Extraction
AGROVOC Term:	Leaves
AGROVOC Term:	Plant extracts
AGROVOC Term:	Solvents
AGROVOC Term:	Ethanol
AGROVOC Term:	Methanol
AGROVOC Term:	Drying
AGROVOC Term:	Ovens
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:54
URI:	http://webagris.upm.edu.my/id/eprint/8103

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