Enhancers in proboscis monkey : A Primer

Hung Hui Chung, . and Lim Leonard Whye Kit, . and Yee Ling Chong, . and Lee Nung Kion, . Enhancers in proboscis monkey : A Primer. pp. 261-276. ISSN 1511-3701

Enhancers are indispensable elements in various developmental stages orchestrating numerous biological processes via the elevation of gene expression with the aid of transcription factors. Enhancer variations have been linked to various onset of genetic diseases highlighting their equal importance as the coding regions in the genome. Despite the first enhancer SV40 been discovered four decades ago the progress in enhancer identification and characterization is still in its infancy. As more genome sequences are made available especially from that of the non-human primates we can finally study the enhancer landscape of these primates that differs evolutionarily from that of human. One interesting genome to investigate is that of the proboscis monkey as it is deemed as one of the most ancient primates alive to date with unique morphological and dietary characteristics; it is also one of the IUCN endangered species with the strong demands for immediate conservation. In this review we provide some justifications and considerations of selecting the proboscis monkey as a model for enhancer landscape discovery. It is hoped that more conservation research and protective measures can come in time to prevent this species from extinction.

Full text available from: Official URL: http://www.pertanika.upm.edu.my/Pertanika%20PAPERS...

Abstract

Enhancers are indispensable elements in various developmental stages orchestrating numerous biological processes via the elevation of gene expression with the aid of transcription factors. Enhancer variations have been linked to various onset of genetic diseases highlighting their equal importance as the coding regions in the genome. Despite the first enhancer SV40 been discovered four decades ago the progress in enhancer identification and characterization is still in its infancy. As more genome sequences are made available especially from that of the non-human primates we can finally study the enhancer landscape of these primates that differs evolutionarily from that of human. One interesting genome to investigate is that of the proboscis monkey as it is deemed as one of the most ancient primates alive to date with unique morphological and dietary characteristics; it is also one of the IUCN endangered species with the strong demands for immediate conservation. In this review we provide some justifications and considerations of selecting the proboscis monkey as a model for enhancer landscape discovery. It is hoped that more conservation research and protective measures can come in time to prevent this species from extinction.

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Item Type:	Article
AGROVOC Term:	Primates
AGROVOC Term:	animal genetics
AGROVOC Term:	Genomes
AGROVOC Term:	Gene sequence
AGROVOC Term:	DNA
AGROVOC Term:	Disease treatment
AGROVOC Term:	Wildlife conservation
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:54
URI:	http://webagris.upm.edu.my/id/eprint/8132

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