Aqueous extract of Etlingera elatior flowers improved blood glucose control kidney function and histology of streptozotocin-induced diabetic rat


Citation

Nor Asiah Muhamad Nor, . and Noor Afifah Azmi, . and Liza Noordin, . and Nor Hidayah Abu Bakar, . and Wan Amir Nizam Wan Ahmad, . Aqueous extract of Etlingera elatior flowers improved blood glucose control kidney function and histology of streptozotocin-induced diabetic rat. pp. 80-91. ISSN 2672-7226

Abstract

Diabetes mellitus (DM) is the most critical health problem of chronic renal disorder that has become a major reason in medical treatments of dialysis and kidney transplantation. In Malaysia Etlingera elatior has been used as a native medicine to reduce blood sugar among diabetic patients. This study aims to evaluate the therapeutic effect of crude aqueous E. elatior flowers extract (AEEFE) on streptozotocin (STZ)- induced diabetic rats taken orally. The effective dose in lowering blood glucose level in acute test was found to be 300 mg/kg in the present study and this was further evaluated in sub-acute test. The fasting blood glucose level and the body weight of the rats were weekly monitored. At the end of the study biochemical parameters were subjected and the kidney histology was examined using hematoxylin and eosin (HE) staining and scanning electron microscope (SEM). From the results AEEFE appeared to significantly reduce the blood glucose level compared to the untreated diabetic rat with consistent body weight. In addition blood urea nitrogen (BUN)has also shown a significant decrease in AEEFE-treated diabetic rats compared to the control group. The histological analysis of kidney rats treated with AEEFEillustrated no change in the size and structure of glomeruli with well-defined glomerular capillaries. Likewise no mesangial hypercellularity was found. SEM analysis has supported present findings by demonstrating well branched podocytes with fenestrated foot processes arranged in parallel. Consequently it is suggested that AEEFE has high potential to reduce blood glucose level without histological changesin renal function system of diabetic patients.


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Abstract

Diabetes mellitus (DM) is the most critical health problem of chronic renal disorder that has become a major reason in medical treatments of dialysis and kidney transplantation. In Malaysia Etlingera elatior has been used as a native medicine to reduce blood sugar among diabetic patients. This study aims to evaluate the therapeutic effect of crude aqueous E. elatior flowers extract (AEEFE) on streptozotocin (STZ)- induced diabetic rats taken orally. The effective dose in lowering blood glucose level in acute test was found to be 300 mg/kg in the present study and this was further evaluated in sub-acute test. The fasting blood glucose level and the body weight of the rats were weekly monitored. At the end of the study biochemical parameters were subjected and the kidney histology was examined using hematoxylin and eosin (HE) staining and scanning electron microscope (SEM). From the results AEEFE appeared to significantly reduce the blood glucose level compared to the untreated diabetic rat with consistent body weight. In addition blood urea nitrogen (BUN)has also shown a significant decrease in AEEFE-treated diabetic rats compared to the control group. The histological analysis of kidney rats treated with AEEFEillustrated no change in the size and structure of glomeruli with well-defined glomerular capillaries. Likewise no mesangial hypercellularity was found. SEM analysis has supported present findings by demonstrating well branched podocytes with fenestrated foot processes arranged in parallel. Consequently it is suggested that AEEFE has high potential to reduce blood glucose level without histological changesin renal function system of diabetic patients.

Additional Metadata

[error in script]
Item Type: Article
AGROVOC Term: Diabetes mellitus
AGROVOC Term: Disease treatment
AGROVOC Term: Flower extracts
AGROVOC Term: Ginger
AGROVOC Term: Zingiberaceae
AGROVOC Term: Experimental animals
AGROVOC Term: Phytochemistry
AGROVOC Term: Scanning microscopy
AGROVOC Term: Blood glucose
AGROVOC Term: Renal function
Depositing User: Mr. AFANDI ABDUL MALEK
Last Modified: 24 Apr 2025 00:54
URI: http://webagris.upm.edu.my/id/eprint/8304

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