The past and current updates on diagnostic aspects of osteoarthritis

M. Ajat, . and Lau S. F., . and P. A. M. Abd Rani, . and Ng A. M. H., . and Tan W. M., . and Norasfaliza R., . and R. Mansor, . The past and current updates on diagnostic aspects of osteoarthritis. pp. 7-12. ISSN 0128-2506

Osteoarthritis (OA) is a progressive joint disease leading to the destruction of joint structures which in turn causes severe and chronic pain to the patient. Since OA is a troubling and disruptive disease numerous researches have been done into diagnosing this disease both in the early and the late stages of the disease. Diagnostic modalities such as radiography computed-tomography (CT) micro-computed tomography (-CT) and magnetic resonance imaging (MRI) have been used in OA research. Not only that more advance measurements and criteria have been established to standardize OA research. Currently the OA research has been delving into proteomic studies to search for potential disease biomarkers. Biomarkers such as urinary C-terminal telopeptide of collagen type 2 (uCTX-II) and cartilage oligometric protein (COMP) have shown potential to be both diagnostic and prognostic biomarkers. For this review paper the developments in diagnostic modalities are discussed focusing more on proteomic and biomarker studies.

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Abstract

Osteoarthritis (OA) is a progressive joint disease leading to the destruction of joint structures which in turn causes severe and chronic pain to the patient. Since OA is a troubling and disruptive disease numerous researches have been done into diagnosing this disease both in the early and the late stages of the disease. Diagnostic modalities such as radiography computed-tomography (CT) micro-computed tomography (-CT) and magnetic resonance imaging (MRI) have been used in OA research. Not only that more advance measurements and criteria have been established to standardize OA research. Currently the OA research has been delving into proteomic studies to search for potential disease biomarkers. Biomarkers such as urinary C-terminal telopeptide of collagen type 2 (uCTX-II) and cartilage oligometric protein (COMP) have shown potential to be both diagnostic and prognostic biomarkers. For this review paper the developments in diagnostic modalities are discussed focusing more on proteomic and biomarker studies.

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Item Type:	Article
AGROVOC Term:	Osteoarthritis
AGROVOC Term:	Joint diseases
AGROVOC Term:	Development research
AGROVOC Term:	Differential diagnosis
AGROVOC Term:	Early diagnosis
AGROVOC Term:	Magnetic resonance imaging
AGROVOC Term:	Radiography
AGROVOC Term:	Tomography
AGROVOC Term:	Biomarkers of exposure (organisms)
AGROVOC Term:	Cartilage
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:54
URI:	http://webagris.upm.edu.my/id/eprint/8348

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