Acute toxicological assessment of seashore mangosteen (Garcinia hombroniana) aqueous extract

R. S. K. Sharma, . and Arifah A. K., . and Mohd Aspollah M. S., . and Z. A. Zakaria, . and Dyary H. O., . and Zuraini A., . and Rasedee A., . and M. N. Somchit, . Acute toxicological assessment of seashore mangosteen (Garcinia hombroniana) aqueous extract. pp. 4-11. ISSN 0128-2506

Garcinia hombroniana has been used in Malay traditional medicine to treat various disorders such as abdominal pain and gonorrhea and little is known about its toxicological properties. This study investigated the acute toxicological effects of the plants leaves aqueous extract using theoral acute toxic class (ATC) method. Twenty-four female Sprague-Dawley rats were divided into T1 T2 T3 and control groups. The T1 T2 and T3 rats administered a single oral dose of 300 2000 and 5000 mg/kg of G. hombroniana leaves aqueous extract respectively.The animals were checked daily for abnormal clinical signs and mortality rate for 14 days. The body weight daily food and water consumption were recorded. The haematological and biochemical parameters of blood as well as relative organ weight and tissues histology such as heart kidney liver and spleen were evaluated. Results have shown significantly decreased (p 0.05) food and water consumption in T2 and T3 rats which returned to normal after 72 hr post administration. No significant differences (p 0.05) in the haematological and serum biochemical parameters in the treated rat groups compared to the untreated control animals. An increase in the relative weight of spleen was noticed in T3 animals. Congestion of the splenic hepatic cardiac and renal tissues was seen in T2 and T3 rats. The oral LD50 was higher than 5000 mg/kg of body weight. Thus it can be concluded that G. hombroniana aqueous extract shows little toxicity in the laboratory rats and the therapeutic potentials should be further investigated.

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Abstract

Garcinia hombroniana has been used in Malay traditional medicine to treat various disorders such as abdominal pain and gonorrhea and little is known about its toxicological properties. This study investigated the acute toxicological effects of the plants leaves aqueous extract using theoral acute toxic class (ATC) method. Twenty-four female Sprague-Dawley rats were divided into T1 T2 T3 and control groups. The T1 T2 and T3 rats administered a single oral dose of 300 2000 and 5000 mg/kg of G. hombroniana leaves aqueous extract respectively.The animals were checked daily for abnormal clinical signs and mortality rate for 14 days. The body weight daily food and water consumption were recorded. The haematological and biochemical parameters of blood as well as relative organ weight and tissues histology such as heart kidney liver and spleen were evaluated. Results have shown significantly decreased (p 0.05) food and water consumption in T2 and T3 rats which returned to normal after 72 hr post administration. No significant differences (p 0.05) in the haematological and serum biochemical parameters in the treated rat groups compared to the untreated control animals. An increase in the relative weight of spleen was noticed in T3 animals. Congestion of the splenic hepatic cardiac and renal tissues was seen in T2 and T3 rats. The oral LD50 was higher than 5000 mg/kg of body weight. Thus it can be concluded that G. hombroniana aqueous extract shows little toxicity in the laboratory rats and the therapeutic potentials should be further investigated.

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Item Type:	Article
AGROVOC Term:	Garcinia
AGROVOC Term:	Leaves
AGROVOC Term:	Leaf extracts
AGROVOC Term:	Acute toxicity
AGROVOC Term:	Laboratory animals
AGROVOC Term:	Rats
AGROVOC Term:	Toxicology
AGROVOC Term:	Weight
AGROVOC Term:	Food consumption
AGROVOC Term:	Water consumption (animals)
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:54
URI:	http://webagris.upm.edu.my/id/eprint/8353

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