Clinical biochemical and histological changes during developement of pregnancy ketosis in goats

M. Zamri Saad, . and Mokrish A., . and Zuki A.B., . and Amirul F. M. A., . and Lai K.S., . and H. A. Hassim, . Clinical biochemical and histological changes during developement of pregnancy ketosis in goats. pp. 1-6. ISSN 0128-2506

Thin does or very over-conditioned does and does carrying with multiple pregnancies are more likely to develop pregnancy ketosis (pregnancy toxaemia). Pregnancy ketosis is one of the metabolic disorders in ruminant animal such as does and ewes during the last weeks of pregnancy (5 “ 6 weeks before gestation) and beside high ketone body levels characterised by free fatty acids levels (FFA). These FFA are derived from the adipose tissue. The ability of adipocytes to respond to changes in the energy balance by secretion of FFA makes this parameter a main indicator for disorder that coincide with changes in energy balance. It is biochemically and endocrinologically characterized by ketosis hypoinsulinemia and an elevation of B- hydroxybtyrate concentration in the plasma free fatty acids (FFA) and cortisol. However the effect of plasma free fatty acid on pathophysiology metabolites and histological changes of this disorder remain poorly understood. Clinical signs often with a slow onset are characterised by neuorological signs like teeth grinding stress and dull eyes. Ketosis also affected on pathological part which characterized by fatty liver. In this review we are focusing various key aspects of the disease with special reference on the clinical biochemical and histological changes during development of pregnancy ketosis in goat population.

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Abstract

Thin does or very over-conditioned does and does carrying with multiple pregnancies are more likely to develop pregnancy ketosis (pregnancy toxaemia). Pregnancy ketosis is one of the metabolic disorders in ruminant animal such as does and ewes during the last weeks of pregnancy (5 “ 6 weeks before gestation) and beside high ketone body levels characterised by free fatty acids levels (FFA). These FFA are derived from the adipose tissue. The ability of adipocytes to respond to changes in the energy balance by secretion of FFA makes this parameter a main indicator for disorder that coincide with changes in energy balance. It is biochemically and endocrinologically characterized by ketosis hypoinsulinemia and an elevation of B- hydroxybtyrate concentration in the plasma free fatty acids (FFA) and cortisol. However the effect of plasma free fatty acid on pathophysiology metabolites and histological changes of this disorder remain poorly understood. Clinical signs often with a slow onset are characterised by neuorological signs like teeth grinding stress and dull eyes. Ketosis also affected on pathological part which characterized by fatty liver. In this review we are focusing various key aspects of the disease with special reference on the clinical biochemical and histological changes during development of pregnancy ketosis in goat population.

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Item Type:	Article
AGROVOC Term:	Goats
AGROVOC Term:	Pregnancy
AGROVOC Term:	Pregnancy toxaemia
AGROVOC Term:	Ketosis
AGROVOC Term:	Clinical examination
AGROVOC Term:	Biochemical reactions
AGROVOC Term:	Animal histology
AGROVOC Term:	Embryonic development
AGROVOC Term:	Free fatty acids
AGROVOC Term:	Cortisol
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:54
URI:	http://webagris.upm.edu.my/id/eprint/8358

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