Comparison of clinical signs and mortality rate in murine model infected with herpes virus isolates from captive wildlife

Zeenathul N. A., . and Shahron N., . and Fuzina N. H., . and Tan S. S., . and Mohd-Azmi M. L., . Comparison of clinical signs and mortality rate in murine model infected with herpes virus isolates from captive wildlife. pp. 37-42. ISSN 9128-2506

Clinical signs cellular infectivity and mortality rate of two closely related alpha-herpesvirus from a gaur (UPMVS/ OS) and a bear (UPMVI9/05) were studied in mice experimentally infected via the nasal route. The grade of viral infection was divided into low (10 and 10�´ pfu/ml) medium (10� and 10� pfu/ml) and high (10�· pfu/ml). Clinically all animals with the exception of controls showed respiratory and neurological signs starting from 36 hpi. Although there were a number of differences in the onset time of clinical signs these were not significant and the types of clinical signs shown were common. Nevertheless there was a significant difference in the mortality rate in which isolate UPMV19/05 from a bear was more pathogenic (83) than the gaur isolate UPMV5/05 (16.7). These results strongly suggest that the consequences of host adaptation of herpesviruses may have been derived from interspecies transmission and underscore the need for extreme caution when managing wild or captive animals in close proximity to bovines.

Full text available from: Official URL: https://www.mavma.org.my/2011-volume-23-issue-no-1...

Abstract

Clinical signs cellular infectivity and mortality rate of two closely related alpha-herpesvirus from a gaur (UPMVS/ OS) and a bear (UPMVI9/05) were studied in mice experimentally infected via the nasal route. The grade of viral infection was divided into low (10 and 10�´ pfu/ml) medium (10� and 10� pfu/ml) and high (10�· pfu/ml). Clinically all animals with the exception of controls showed respiratory and neurological signs starting from 36 hpi. Although there were a number of differences in the onset time of clinical signs these were not significant and the types of clinical signs shown were common. Nevertheless there was a significant difference in the mortality rate in which isolate UPMV19/05 from a bear was more pathogenic (83) than the gaur isolate UPMV5/05 (16.7). These results strongly suggest that the consequences of host adaptation of herpesviruses may have been derived from interspecies transmission and underscore the need for extreme caution when managing wild or captive animals in close proximity to bovines.

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Item Type:	Article
AGROVOC Term:	Wildlife
AGROVOC Term:	Mortality
AGROVOC Term:	Herpesvirus
AGROVOC Term:	Infectivity
AGROVOC Term:	Gaurs
AGROVOC Term:	Infection
AGROVOC Term:	Pathogenicity
AGROVOC Term:	Transmissions
AGROVOC Term:	Bovines
AGROVOC Term:	Inoculation
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:54
URI:	http://webagris.upm.edu.my/id/eprint/8406

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