Assessment of cell mediated immune response in spontaneously occurring canine mammary gland tumours by leucocytemiggration inhibition test (LMIT)

Lonkar P. S., . and Adak A., . Assessment of cell mediated immune response in spontaneously occurring canine mammary gland tumours by leucocytemiggration inhibition test (LMIT). pp. 17-20. ISSN 9128-2506

In the present study cell mediated immune response in the mammary gland tumour-bearing bitches was studied by evaluating functional capacity of sensitised lymphocytes using Leucocyte Migration Inhibition Test (LMIT). Cell membrane antigens (allogenic type) of different molecular weights separated from mammary gland tumour tissue were subjected to LMIT against leucocytes separated from twenty tumour-bearing bitches and six apparently healthy dogs used as control group. Statistically the tumour bearing dogs had significantly lower migration index values in comparison to healthy control dogs. Thus leucocytes separated fom tumour-bearing animals showed positive LMIT response while there was normal migration in the healthy control dogs. It is seen that the functional capacity of T Lymphocytes in the mammary gland tumour-bearing bitches played a major role in cellular immunity and was not affected as indicated by migration inhibition index.

Full text available from: Official URL: https://www.mavma.org.my/2009-volume-21-issue-no-2...

Abstract

In the present study cell mediated immune response in the mammary gland tumour-bearing bitches was studied by evaluating functional capacity of sensitised lymphocytes using Leucocyte Migration Inhibition Test (LMIT). Cell membrane antigens (allogenic type) of different molecular weights separated from mammary gland tumour tissue were subjected to LMIT against leucocytes separated from twenty tumour-bearing bitches and six apparently healthy dogs used as control group. Statistically the tumour bearing dogs had significantly lower migration index values in comparison to healthy control dogs. Thus leucocytes separated fom tumour-bearing animals showed positive LMIT response while there was normal migration in the healthy control dogs. It is seen that the functional capacity of T Lymphocytes in the mammary gland tumour-bearing bitches played a major role in cellular immunity and was not affected as indicated by migration inhibition index.

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Item Type:	Article
AGROVOC Term:	Mammary glands
AGROVOC Term:	Animal tumours
AGROVOC Term:	Inhibition
AGROVOC Term:	Immune response
AGROVOC Term:	Immunity
AGROVOC Term:	Migration
AGROVOC Term:	Mammary glands
AGROVOC Term:	Dogs
AGROVOC Term:	Lymphocytes
AGROVOC Term:	Bitches
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:54
URI:	http://webagris.upm.edu.my/id/eprint/8427

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