Increase in plasma and urine fibronectin concentrations during development of puromycin aminonucleoside-induced nephrotic syndrome in rats


Citation

Rasedee A, . and Feldman B. F., . Increase in plasma and urine fibronectin concentrations during development of puromycin aminonucleoside-induced nephrotic syndrome in rats. pp. 119-125. ISSN 9128-2506

Abstract

Nephrotic syndrome was induced in rats with 15gm puromycin aminonucleoside (PAN)/100g body weight. Urine and plasma fibronectin were analyzed in these rats by rocket immunoelectrophoresis was not detected in urine between days 0 (control) and days 4 inclusive post-PAN. At day 6 post-PAN the urine fibronectin concentration was 146.6 39.9 g/ml. The fibronection concentration further increased to 317.8 14.4g/ml urine at day 8 and 337.4 g/ml urine at day 10 post-PAN. The detection of fibronection in urine coincided with significant elevation of plasma fibronectin concentration (P0.05). We conclude that there is an increased urine fibronectin concentration in PAN-induced rat nephrotic symdrome a result of increase in plasma fibronection concentration which has exceeded the renal threshold.


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Abstract

Nephrotic syndrome was induced in rats with 15gm puromycin aminonucleoside (PAN)/100g body weight. Urine and plasma fibronectin were analyzed in these rats by rocket immunoelectrophoresis was not detected in urine between days 0 (control) and days 4 inclusive post-PAN. At day 6 post-PAN the urine fibronectin concentration was 146.6 39.9 g/ml. The fibronection concentration further increased to 317.8 14.4g/ml urine at day 8 and 337.4 g/ml urine at day 10 post-PAN. The detection of fibronection in urine coincided with significant elevation of plasma fibronectin concentration (P0.05). We conclude that there is an increased urine fibronectin concentration in PAN-induced rat nephrotic symdrome a result of increase in plasma fibronection concentration which has exceeded the renal threshold.

Additional Metadata

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Item Type: Article
AGROVOC Term: Nephrosis
AGROVOC Term: Syndromes
AGROVOC Term: Rats
AGROVOC Term: Immunoelectrophoresis
AGROVOC Term: Urine
AGROVOC Term: Plasma proteins
AGROVOC Term: Glycoproteins
AGROVOC Term: Hypoproteinaemia
AGROVOC Term: Proteinuria
Depositing User: Mr. AFANDI ABDUL MALEK
Last Modified: 24 Apr 2025 00:54
URI: http://webagris.upm.edu.my/id/eprint/8454

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