Changes in the lungs of goats with acute pneumonia following experimental challenge with Pasteurella haemolytica and Pasteurella multocida

M. Zamri Saad, . and Maswati M. A., . and Effendy A. W. M., . and Jasni S., . Changes in the lungs of goats with acute pneumonia following experimental challenge with Pasteurella haemolytica and Pasteurella multocida. pp. 67-70. ISSN 9128-2506

Forty goats approximately 7 months old were divided into 4 groups of 10 animals each. Those in group i were challenged intratracheally with 4 mL inoculum containing 1.0 X 10� cfu/mL of Pasteurella haemolytica A2 isolated from pneumonic lungs of a goat. Goats in group 2 were similarly challenged with P. haemolytica A2 isolated from the nasal cavity of a healthy goat and goats in groups 3 and 4 were challenged with P. multocida type A and D isolated from pneumonic lungs respectively. Two goats from group 1 four from group 3 and five from group 4 died within 8 h of challenge. Gross changes included pulmonary oedema petechiations and patches of acute pneumonia while histological changes included sequestration of neutrophilic leucocytes in capillaries thrombosis and endothelial degeneration. These changes were typical of those caused by endotoxin on the endothelium of pulmonary blood vessels. P. haemolytica was not isolated from blood whereas P. multocida was readily observed in and isolated from blood. It is concluded that acute lesions in both P. haemolytica and P. multocida enfections of goatd involved endotoxin and developed in similar manner. P. haemolytica infection however resulted in toxaemia rather than the septicaemia as in P. multocida infections.

Full text available from: Official URL: https://www.mavma.org.my/1999-volume-11-issue-no-2...

Abstract

Forty goats approximately 7 months old were divided into 4 groups of 10 animals each. Those in group i were challenged intratracheally with 4 mL inoculum containing 1.0 X 10� cfu/mL of Pasteurella haemolytica A2 isolated from pneumonic lungs of a goat. Goats in group 2 were similarly challenged with P. haemolytica A2 isolated from the nasal cavity of a healthy goat and goats in groups 3 and 4 were challenged with P. multocida type A and D isolated from pneumonic lungs respectively. Two goats from group 1 four from group 3 and five from group 4 died within 8 h of challenge. Gross changes included pulmonary oedema petechiations and patches of acute pneumonia while histological changes included sequestration of neutrophilic leucocytes in capillaries thrombosis and endothelial degeneration. These changes were typical of those caused by endotoxin on the endothelium of pulmonary blood vessels. P. haemolytica was not isolated from blood whereas P. multocida was readily observed in and isolated from blood. It is concluded that acute lesions in both P. haemolytica and P. multocida enfections of goatd involved endotoxin and developed in similar manner. P. haemolytica infection however resulted in toxaemia rather than the septicaemia as in P. multocida infections.

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Item Type:	Article
AGROVOC Term:	Goats
AGROVOC Term:	Lungs
AGROVOC Term:	Pneumonia
AGROVOC Term:	Pathology
AGROVOC Term:	Pasteurella haemolytica
AGROVOC Term:	Pasteurella multocida
AGROVOC Term:	Respiratory diseases
AGROVOC Term:	Infection
AGROVOC Term:	Oedema
AGROVOC Term:	Histopathology
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:54
URI:	http://webagris.upm.edu.my/id/eprint/8834

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