Protective immunity against equine herpesvirus type-1 infection following immunisation of mice with a non-pathogenic equine herpesvirus type-4


Citation

Mohd Azmi M. L., . Protective immunity against equine herpesvirus type-1 infection following immunisation of mice with a non-pathogenic equine herpesvirus type-4. pp. 71-77. ISSN 9128-2506

Abstract

Protection against equine herpesvirus type-1 (EHV-1) infection was studied in mice following immunisation with its related heterologous virus EHV-4. The EHV was found to be non-pathogenic in mice. Inoculation of mice with either live or heat-inactivated EHV-4 stimulated IgG antibody response to both EHV-4 and EHV-1 antigens. Similar cross-reactive phenomenon was observed in mice inoculated with EHV-1. A significant level of virus-specific antibody was detected when the hyperimmune sera were tested by the virus neutralisation assay but not by ELISA. Antibody production following inoculation of mice either with live or heat-inactivated EHV were generally at similar levels. Hhowever when mice were challenged with EHV-1 protection was only observed in mice immunised with live EHV-4. It is thus suggested that live EHV-4 can induce protective immunity against severe disease of EHV-1 and could possibly be used as an immunising agent to stimulate protective immunity against heterologous virus EHV-1.


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Abstract

Protection against equine herpesvirus type-1 (EHV-1) infection was studied in mice following immunisation with its related heterologous virus EHV-4. The EHV was found to be non-pathogenic in mice. Inoculation of mice with either live or heat-inactivated EHV-4 stimulated IgG antibody response to both EHV-4 and EHV-1 antigens. Similar cross-reactive phenomenon was observed in mice inoculated with EHV-1. A significant level of virus-specific antibody was detected when the hyperimmune sera were tested by the virus neutralisation assay but not by ELISA. Antibody production following inoculation of mice either with live or heat-inactivated EHV were generally at similar levels. Hhowever when mice were challenged with EHV-1 protection was only observed in mice immunised with live EHV-4. It is thus suggested that live EHV-4 can induce protective immunity against severe disease of EHV-1 and could possibly be used as an immunising agent to stimulate protective immunity against heterologous virus EHV-1.

Additional Metadata

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Item Type: Article
AGROVOC Term: Horses
AGROVOC Term: Viral diseases
AGROVOC Term: Equine herpesvirus
AGROVOC Term: Herpesviridae
AGROVOC Term: Animal diseases
AGROVOC Term: Disease control
AGROVOC Term: Experimental infection
AGROVOC Term: Immunization
AGROVOC Term: Enzyme linked immunosorbent assay
AGROVOC Term: Antibodies
Depositing User: Mr. AFANDI ABDUL MALEK
Last Modified: 24 Apr 2025 00:54
URI: http://webagris.upm.edu.my/id/eprint/8835

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